sphingosine-1-phosphate

SPNS2 exports sphingosine-1-phosphate and imports glucose Spinster homolog 2 (SPNS2) exports the bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P) out of cells to regulate processes important for health and diseases. However, the molecular mechanism underlying SPNS2 transport...

https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00522-1 Highlights • Female long COVID (LC) patients show heightened immune activation and inflammation • Disrupted sex hormone levels differ between male and female LC patients • Neuroinflammatory gene signatures may explain...

Characterizing post-COVID-19 syndrome in multiple sclerosis: Vaccine status, infection burden, and therapy categories as predictors Deepak Sharma ∙ Christian P. Kamm ∙ Robert Hoepner ∙ Iris-Katharina Penner ∙ Thomas Nyffeler ∙ Lara Diem [Line breaks added] Background Post-COVID-19 syndrome...

Erythrocytes as a Source of Exerkines Exercise activates many metabolic and signaling pathways in skeletal muscle and other tissues and cells, causing numerous systemic beneficial metabolic effects. Traditionally recognized for their principal role in oxygen (O2) transport, erythrocytes have...

Abstract Specialized immune cells that reside in tissues orchestrate diverse biological functions by communicating with parenchymal cells1. The contribution of the innate immune compartment in the meninges and the central nervous system (CNS) is well-characterized; however, whether cells of the...

A research perspective on sphingolipid metabolism and myalgic encephalomyelitis/chronic fatigue syndrome Xiao, Junhua No abstract. Link | PDF (Neural Regeneration Research)

A blood-based mRNA signature distinguishes people with Long COVID from recovered individuals Missailidis, Daniel; Ebrahimie, Esmaeil; Mohammadi-Dehcheshmeh, Manijeh; Allan, Claire; Sanislav, Oana; Fisher, Paul Robert; Gras, Stephanie; Annesley, Sarah Jane Long COVID is a debilitating condition...

Metabolic network analysis of pre-ASD newborns and 5-year-old children with autism spectrum disorder Lingampelly, Sai Sachin; Naviaux, Jane C.; Heuer, Luke S.; Monk, Jonathan M.; Li, Kefeng; Wang, Lin; Haapanen, Lori; Kelland, Chelsea A.; Van de Water, Judy; Naviaux, Robert K. Classical...

Full title: Chronic inflammation, neuroglia dysfunction, and plasmalogen deficiency as a new pathobiological hypothesis addressing the overlap between post-COVID-19 symptoms and myalgic encephalomyelitis/chronic fatigue syndrome Highlights Plasmalogens (Pls) are lipids containing a...

Cancer-related cognitive impairment (CRCI) is a major neurotoxicity affecting more than 50% of cancer survivors. The underpinning mechanisms are mostly unknown, and there are no FDA-approved interventions. Sphingolipidomic analysis of mouse prefrontal cortex and hippocampus, key sites of...