synaptic loss

As a lot of the genetic evidence points towards synapses, one very simple hypothesis is a general and randomised loss of synapses throughout the nervous system. I want to vent a few disorganised thoughts and questions I have about that here. Tell me if it sounds implausible. ----------------...

C1q and immunoglobulins mediate activity-dependent synapse loss in the adult brain INTRODUCTION Synaptic elimination is a fundamental process that can engage microglia and the classical complement cascade, yet the mechanisms that specify which synapses are targeted by complement component 1q...

Neurons undergo IFNγ-driven persistent epigenetic shifts and synaptopathy in encephalitis In infectious and autoimmune disorders of the central nervous system, neurons can become cognate immunological targets of cytotoxic T cells, leading to persistent functional and synaptic impairments...