tlr-4

  1. SNT Gatchaman

    Persistent Monocytic Bioenergetic Impairment and Mitochondrial DNA Damage in PASC Patients with Cardiovascular Complications, 2025, Semo+

    Persistent Monocytic Bioenergetic Impairment and Mitochondrial DNA Damage in PASC Patients with Cardiovascular Complications Semo, Dilvin; Shomanova, Zornitsa; Sindermann, Jürgen; Mohr, Michael; Evers, Georg; Motloch, Lukas J.; Reinecke, Holger; Godfrey, Rinesh; Pistulli, Rudin Cardiovascular...
    • SNT Gatchaman
    • Thread
    • caspase caspase-1 glutathione grp78 il-1b immunoparalysis inflammasome mitochochria monocytes mtdna oxidative stress reactive oxygen species seahorse tlr-4 tlr-9
    • Replies: 2
    • Forum: Long Covid research
  2. SNT Gatchaman

    CircSARS-CV2-N1368 from SARS-CoV-2 impairs endothelial cell function through the upregulation of ATF7 to activate TLR4/NF-κB/ROS signaling, 2025, Wen+

    CircSARS-CV2-N1368 from SARS-CoV-2 impairs endothelial cell function through the upregulation of ATF7 to activate TLR4/NF-κB/ROS signaling Wen, Yi-hong; Zhao, Heng-li; Wu, Shao-yu; Jiang, Jia-xue; Gao, Yuan; Wang, Zi-fan; Liu, Xiao-yao; Yu, Fei; Ou, Tao; Zhao, An-zhi; Chen, Li-wen; Fang...
    • SNT Gatchaman
    • Thread
    • atf7 endothelial cells endothelial dysfunction micro-rna nf-κb reactive oxygen species tlr-4
    • Replies: 0
    • Forum: Long Covid research
  3. SNT Gatchaman

    Dysrupted microbial tryptophan metabolism associates with SARS-CoV-2 acute inflammatory responses and long COVID, 2024, Yao et al.

    Dysrupted microbial tryptophan metabolism associates with SARS-CoV-2 acute inflammatory responses and long COVID Lu Yao; Hannah Devotta; Junhui Li; Nonhlanhla Lunjani; Corinna Sadlier; Aonghus Lavelle; Werner C. Albrich; Jens Walter; Paul W. O’Toole; Liam O’Mahony Protection against severe...
    • SNT Gatchaman
    • Thread
    • gut microbiome il-10 il-22 innate immune system interferon-stimulated genes saa sting tlr-3 tlr-4 tryptophan
    • Replies: 1
    • Forum: Long Covid research
  4. SNT Gatchaman

    Cytokine Profile in Patients with Postacute Sequelae of COVID-19, 2024, Ghorra et al.

    Cytokine Profile in Patients with Postacute Sequelae of COVID-19 Nathalie Ghorra; Alexandros Popotas; Tatiana Besse-Hammer; Anne Rogiers; Francis Corazza; Carole Nagant The enduring impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its disease manifestation, COVID-19...
  5. SNT Gatchaman

    Spinal cord microglia drive sex differences in ethanol-mediated PGE2-induced allodynia, 2024, Alexander et al.

    Spinal cord microglia drive sex differences in ethanol-mediated PGE2-induced allodynia Alexander; Reed; Burton The mechanisms of how long-term alcohol use can lead to persistent pain pathology are unclear. Understanding how earlier events of short-term alcohol use can lower the threshold of...
  6. SNT Gatchaman

    TLR2/4 are novel activating receptors for SARS-CoV-2 spike protein on NK cells, 2024, Landolina et al.

    TLR2/4 are novel activating receptors for SARS-CoV-2 spike protein on NK cells Landolina, Nadine; Ricci, Biancamaria; Veneziani, Irene; Alicata, Claudia; Mariotti, Francesca Romana; Pelosi, Andrea; Quatrini, Linda; Mortari, Eva Piano; Carsetti, Rita; Vacca, Paola; Tumino, Nicola; Azzarone...
  7. SNT Gatchaman

    Review Aquaporins: Gatekeepers of Fluid Dynamics in Traumatic Brain Injury, 2024, Czyżewski et al.

    Aquaporins: Gatekeepers of Fluid Dynamics in Traumatic Brain Injury Czyżewski, Wojciech; Litak, Jakub; Sobstyl, Jan; Mandat, Tomasz; Torres, Kamil; Staśkiewicz, Grzegorz Aquaporins (AQPs), particularly AQP4, play a crucial role in regulating fluid dynamics in the brain, impacting the...
  8. E

    Altered response to Toll-like receptor 4 activation in fibromyalgia: A low-dose, human experimental endotoxemia pilot study 2023 Jones, Younger et al

    In this pilot study, a human intravenous injection of low-dose endotoxin (lipopolysaccharide, LPS) model was used to test if fibromyalgia is associated with altered immune responses to Toll-like receptor 4 (TLR4) activation. Eight women with moderately-severe fibromyalgia and eight healthy...
  9. Andy

    Unique pathways downstream of TLR-4 and TLR-7 activation: sex-dependent behavioural, cytokine, and metabolic consequences 2024 Dunstan et al

    [In mice] Introduction: Post-infection syndromes are characterised by fatigue, muscle pain, anhedonia, and cognitive impairment; mechanistic studies exploring these syndromes have focussed on pathways downstream of Toll-like receptor (TLR) 4 activation. Here, we investigated the mechanistic...
  10. SNT Gatchaman

    Divergent mechanisms regulate TLR4 expression on PBMCs following workload-matched exercise in normoxic and hypoxic environments, 2023, et al.

    Divergent mechanisms regulate TLR4 expression on peripheral blood mononuclear cells following workload-matched exercise in normoxic and hypoxic environments Jeremy B. Ducharme ; Zachary J. McKenna ; Jonathan W. Specht ; Zachary J. Fennel ; Quint N. Berkemeier ; Michael R. Deyhle Exercise...
  11. SNT Gatchaman

    Near-Infrared Light Exposure Triggers ROS to Downregulate Inflammatory Cytokines Induced by SARS Spike Protein in Human Cell Culture, 2023, Aguida +

    Near-Infrared Light Exposure Triggers ROS to Downregulate Inflammatory Cytokines Induced by SARS-CoV-2 Spike Protein in Human Cell Culture Aguida, Blanche; Chabi, Marie-Marthe; Baouz, Soria; Mould, Rhys; Bell, Jimmy D.; Pooam, Marootpong; André, Sebastien; Archambault, Dominique; Ahmad...
  12. SNT Gatchaman

    Preliminary Evidence of the Differential Expression of HERVs in Kawasaki Disease and SARS-CoV-2-Associated MIS-C, 2023, Balestrieri et al.

    Preliminary Evidence of the Differential Expression of Human Endogenous Retroviruses in Kawasaki Disease and SARS-CoV-2-Associated Multisystem Inflammatory Syndrome in Children Balestrieri, Emanuela; Corinaldesi, Elena; Fabi, Marianna; Cipriani, Chiara; Giudice, Martina; Conti, Allegra...
    • SNT Gatchaman
    • Thread
    • children herv herv-k herv-w il-6 kawasaki mis-c nf-κb retrovirus sars-cov-2 spike protein syncitin tlr-4
    • Replies: 0
    • Forum: Long Covid research
  13. SNT Gatchaman

    Mitochondrial DNA damage triggers spread of Parkinson’s disease-like pathology, 2023, Tresse et al.

    Mitochondrial DNA damage triggers spread of Parkinson’s disease-like pathology Tresse, Emilie; Marturia-Navarro, Joana; Sew, Wei Qi Guinevere; Cisquella-Serra, Marina; Jaberi, Elham; Riera-Ponsati, Lluis; Fauerby, Natasha; Hu, Erling; Kretz, Oliver; Aznar, Susana; Issazadeh-Navikas, Shohreh In...
  14. Andy

    Moderate Exercise Increases Expression for Sensory, Adrenergic, and Immune Genes in CFS Patients But Not in Normal Subjects 2009 Light et al

    [A study from 2009.] Abstract Chronic fatigue syndrome (CFS) is characterized by debilitating fatigue, often accompanied by widespread muscle pain that meets criteria for fibromyalgia syndrome (FMS). Symptoms become markedly worse after exercise. Previous studies implicated dysregulation of...
  15. SNT Gatchaman

    The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity, 2015, Heinz et al.

    The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity Heinz; Baumann; Köberlin; Snijder; Gawish; Shui; Sharif; Aspalter; Müller; Kandasamy; Breitwieser; Pichlmair; Bruckner; Rebsamen; Blüml; Karonitsch; Fauster; Colinge; Bennett; Knapp; Superti-Furga Lipid metabolism and...
  16. Wyva

    Genetic Risk Factors for Severe and Fatigue Dominant Long COVID and Commonalities with ME/CFS Identified by Combinatorial Analysis, 2023, Taylor et al

    Abstract Background Long COVID is a debilitating chronic condition that has affected over 100 million people globally. It is characterized by a diverse array of symptoms, including fatigue, cognitive dysfunction and respiratory problems. Studies have so far largely failed to identify genetic...
    • Wyva
    • Thread
    • circadian genetics long covid neuroligin risk factors slc15a4 tlr-4
    • Replies: 26
    • Forum: ME/CFS research
  17. SNT Gatchaman

    Preprint Extracellular vesicles promote autophagy in human microglia through lipid raft-dependent mechanisms, 2023, Romenskaja et al.

    Extracellular vesicles promote autophagy in human microglia through lipid raft-dependent mechanisms Diana Romenskaja; Ugne Jonavice; Augustas Pivoriunas Autophagy dysfunction has been closely related with pathogenesis of many neurodegenerative diseases and therefore represents a potential...
  18. SNT Gatchaman

    Preprint Respiratory syncytial virus directly binds miR-26, miR-27, and let-7 to de-repress gene targets through canonical and non-canonical mechanisms, 2023

    Respiratory syncytial virus directly binds miR-26, miR-27, and let-7 to de-repress gene targets through canonical and non-canonical mechanisms Sarah Ressel; Sujai Kumar; Jose Roberto Bermudez-Barrientos; Katrina Gordon; Julia Lane; Jin Wu; Cei Abreu-Goodger; Jurgen Schwarze; Amy H Buck Specific...
  19. Andy

    Sphingosine-1-phosphate receptor 1 activation in the central nervous system drives cisplatin-induced cognitive impairment, 2022, Squillace et al

    Cancer-related cognitive impairment (CRCI) is a major neurotoxicity affecting more than 50% of cancer survivors. The underpinning mechanisms are mostly unknown, and there are no FDA-approved interventions. Sphingolipidomic analysis of mouse prefrontal cortex and hippocampus, key sites of...
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