tlr-7

Consequences of sex differences in Type I IFN responses for the regulation of antiviral immunity Pujantell, Maria; Altfeld, Marcus Abstract The immune system protects us from pathogens, such as viruses. Antiviral immune mechanisms aim to limit viral replication, and must maintain immunological...

De novo COVID-19-associated insulin resistance drives dysregulated neutrophil extracellular trap formation (NETosis) four months after infection Abstract Background Glucose metabolism disorders (GMDs) are established risk factors for severe COVID-19, but increasing evidence indicates that...

Whole genome sequence meta-analyses reveal common and rare genetic associations with critical COVID-19 In susceptible patients, COVID-19 causes life-threatening disease driven by immune-mediated inflammatory lung injury. We have previously shown that multiple common host genetic variants are...

SARS-CoV-2 spike triggers TLR7-dependent endolysosome dysfunction and senescence in human astrocytes SARS-CoV-2 infection is associated with long-lasting neuropsychiatric and cognitive symptoms, collectively referred to as neuro-PASC. Emerging studies indicates that accelerate brain aging and...

Cytokine Profile in Patients with Postacute Sequelae of COVID-19 Nathalie Ghorra; Alexandros Popotas; Tatiana Besse-Hammer; Anne Rogiers; Francis Corazza; Carole Nagant The enduring impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its disease manifestation, COVID-19...

[In mice] Introduction: Post-infection syndromes are characterised by fatigue, muscle pain, anhedonia, and cognitive impairment; mechanistic studies exploring these syndromes have focussed on pathways downstream of Toll-like receptor (TLR) 4 activation. Here, we investigated the mechanistic...