unfolded protein response

Unraveling the Connection: Pain and Endoplasmic Reticulum Stress Kawanaka, Ryoko; Jin, Hisayo; Aoe, Tomohiko Pain is a complex and multifaceted experience. Recent research has increasingly focused on the role of endoplasmic reticulum (ER) stress in the induction and modulation of pain. The ER...

Mitochondrial quality control pathways sense mitochondrial protein import Laurie P. Lee-Glover; Timothy E. Shutt Mitochondrial quality control (MQC) mechanisms are required to maintain a functional proteome, which enables mitochondria to perform a myriad of important cellular functions from...

The Role of the Hypoxia-Related Unfolded Protein Response UPR in the Tumor Microenvironment Bartoszewska, Sylwia; Collawn, James F.; Bartoszewski, Rafal Despite our understanding of the unfolded protein response (UPR) pathways, the crosstalk between the UPR and the complex signaling networks...

Hypoxia activates the unfolded protein response signaling network: An adaptive mechanism for endometriosis Zhou, Yong; Jin, Yang; Wang, Yuan; Wu, Ruijin Endometriosis (EMS) is a chronic gynecological disease that affects women of childbearing age. However, the exact cause remains unclear. The...

Abstract The endoplasmic reticulum (ER) is an organelle responsible for the post-translational folding and modification of proteins. Under stress conditions, such as physical exercise, there is accumulation of misfolded proteins. The increased load of proteins in the ER results in ER stress...