wirth

Laxity Comes with Consequences: Connective Tissue Disorders and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Wirth, Klaus J. Abstract ME/CFS patients suffer from manifestations of disturbed connective tissue including ligament laxity, hypermobility, craniocervical instability...

https://www.preprints.org/frontend/manuscript/83de3b17750c8bef6d571f548f84b5e8/download_pub Abstract Hypovolemia and orthostatic intolerance are hallmark features of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) but remain incompletely understood. This review summarizes the...

Abstract Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and post-COVID-19 syndrome share a symptom profile, including severe fatigue, cognitive dysfunction, exertional intolerance, sleep disturbances, hypervigilance, and the paradoxical state of being “wired but tired.” A...

I'm not sure where this should go, or to be honest what exactly its about. The host is a cardiologist who's videos on blood pressure I have watched. However this is not a direct cardiology related video. The only notes are: I am not familiar with either of the people he is interviewing, but I'm...

Since things will likely be a bit quieter over the holidays in terms of new research, I wanted to start a discussion on a topic that really interests me. I’m sure a thread like this may have existed before, but as new studies are constantly being published, opinions and perspectives tend to...

Now published - see post #7 Preprint https://www.preprints.org/manuscript/202509.2242/v1 Authors: Klaus Wirth, Jürgen M. Steinacker Abstract Severely ill ME/CFS patients are bedridden and suffer from hypersensitivities against light and noise, severe orthostatic intolerance reducing...

ABSTRACT Background Recent studies provide strong evidence for a key role of skeletal muscle pathophysiology in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). In a 2021 review article on the pathophysiology of ME/CFS, we postulated that hypoperfusion and ischemia can result in...

Mitodicure GmbH, the company run by Klaus Wirth, has filed 3 patents for drugs aimed at the treatment of ME/CFS and related conditions. One drug is a THERAPEUTIC AGENT WITH SODIUM-HYDROGEN ANTIPORTER 1 INHIBITORY ACTIVITY, another is THERAPEUTIC AGENT WITH PHOSPHODIESTERASE-7 INHIBITORY ACTIVITY...

Full title: Microvascular Capillary and Precapillary Cardiovascular Disturbances Strongly Interact to Severely Affect Tissue Perfusion and Mitochondrial Function in ME/CFS Evolving from the Post COVID-19 Syndrome Abstract Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a...

Abstract Background Muscle fatigue and pain are key symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Although the pathophysiology is not yet fully understood, there is ample evidence for hypoperfusion which may result in electrolyte imbalance and sodium overload in...

Full title: Dyspnea in Post-COVID Syndrome following Mild Acute COVID-19 Infections: Potential Causes and Consequences for a Therapeutic Approach Abstract Dyspnea, shortness of breath, and chest pain are frequent symptoms of post-COVID syndrome (PCS). These symptoms are unrelated to organ...

An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome Klaus J. Wirth, Carmen Scheibenbogen and Friedemann Paul Abstract There is accumulating evidence of endothelial dysfunction, muscle and cerebral hypoperfusion in Myalgic...

Abstract Chronic Fatigue Syndrome or Myalgic Encephaloymelitis (ME/CFS) is a frequent debilitating disease with an enigmatic etiology. The finding of autoantibodies against ß2-adrenergic receptors (ß2AdR) prompted us to hypothesize that ß2AdR dysfunction is of critical importance in the...

Review: A Unifying Hypothesis of the Pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Recognitions from the finding of autoantibodies against ß2-adrenergic receptors KlausWirtha CarmenScheibenbogen...