A Controlled Clinical Trial with a Specifically Configured RNA Drug, Poly(I). POly(C12U), in Chronic Fatigue Syndrome - 1994 Strayer, Cheney et al

Sly Saint · Mar 1, 2020

Clinical Infectious Diseases, Volume 18, Issue Supplement_1, January 1994, Pages S88–S95, https://doi.org/10.1093/clinids/18.Supplement_1.S88
Published:
01 January 1994

Abstract
Chronic fatigue syndrome (CFS) is a physically debilitating illness associated with immunologic abnormalities, viral reactivation, and impairment of cognition. In a randomized, multicenter, placebo-controlled, double-blind study of 92 patients meeting the CFS case definition of the Centers for Disease Control and Prevention, the response of several laboratory and clinical variables to an antiviral and immunomodulatory drug, poly(I) · poly(C12U), was determined.

Measures of clinical response included Karnofsky performance score, a cognition scale derived from a self-administered instrument assessing symptomatology (SCL-90-R), an activities of daily living scale, and exercise treadmill performance.

After 24 weeks, patients receiving poly(I) · poly(C12U) had higher scores for both global performance and perceived cognition than did patients receiving placebo. In particular, patients given poly(I) · poly(C12U) had increased Karnofsky performance scores (P < .03), exhibited a greater ability to do work during exercise treadmill testing (P = .01), displayed an enhanced capacity to perform the activities of daily living (P < .04), had a reduced cognitive deficit (P = .05), and required less use of other medications (P < .05).
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https://academic.oup.com/cid/article-abstract/18/Supplement_1/S88/317068?redirectedFrom=fulltext

sci-hub.tw/10.1093/clinids/18.supplement_1.s88

one for the library(?)
eta: it is interesting to read the full version on sci-hub and see the barage of tests they did and the results eg treadmill

Andy · Feb 29, 2020

poly(I) · poly(C12U)
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From what I can see from a quick Google, that is Ampligen.

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A Controlled Clinical Trial with a Specifically Configured RNA Drug, Poly(I). POly(C12U), in Chronic Fatigue Syndrome - 1994 Strayer, Cheney et al

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A Controlled Clinical Trial with a Specifically Configured RNA Drug, Poly(I). POly(C12U), in Chronic Fatigue Syndrome - 1994 Strayer, Cheney et al

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Andy Committee Member

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