Discussion in 'Treating POTS and Orthostatic Intolerance' started by Andy, Jun 26, 2019.
Open access at www.sciencedirect.com/science/article/pii/S2589909019300061
This was the commentary posted by Dysautonomia International in June (copied from a Facebook user, so sorry I don't have a source link). Researchers in Oaklahoma carrying out work on alpha-1 & beta-1 adrenergic auto-antibodies had doubts about the test they were working on and spent a long time figuring out that norepinephrine in serum samples can artificially elevate a1AR and ß1AR activity. This is important for others working in the same area.
I noticed that the date of the comment you posted is 2014. Is that a typo? Or was that a comment about one of the previous studies?
I did find this more recent blog post on the Dysautonomia International Web Site:
But I have no idea what the blog post adds to this specific thread since the science is way above my head.
No, it is not a typo, and not another study. The link you provided has a little more info (relevant section pasted below) that explains "2014 Conference" refers to when and where the samples were collected. The link in the quote below does refer to the paper in this thread.
It seems it took 5 years to get good measurements - they eventually figured out that norepinephrine affected the test.
Thank you @wigglethemouse - my brain was simply unable to absorb the information!
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