A Pill for Sleep Apnea Could Be on the Horizon

[Jaybee00]

https://www.nytimes.com/2025/07/23/well/apnimed-sleep-apnea-clinical-trial-ad109.html?unlocked_article_code=1.Z08.IilL.Le4sL3ox3fpf&smid=nytcore-ios-share&referringSource=articleShare

 

[Jaybee00]

AD109 (aroxy 2.5mg/ato 75 mg)

 

[hotblack]

Press release on Phase 3 Trial results here, which has more details and links to trial pages etc

Apnimed Reports Positive Topline Results from Second Phase 3 Trial of AD109, Reinforcing Potential of First Oral Pill for Obstructive Sleep Apnea - Apnimed

Apnimed releases positive topline Phase 3 results for LunAIRo, the second Phase 3 clinical trial of AD109, meeting its primary endpoint, highlighting that AD109 met the primary endpoint, demonstrating a reduction in apnea-hypopnea index (AHI, p

apnimed.com

And info from an earlier paper

The Combination of Aroxybutynin and Atomoxetine in the Treatment of Obstructive Sleep Apnea (MARIPOSA): A Randomized Controlled Trial - PubMed

<span><b>Rationale:</b> Obstructive sleep apnea (OSA) is a common sleep disorder for which the principal treatment option, continuous positive airway pressure, is often poorly tolerated. There is currently no approved pharmacotherapy for OSA. However, recent studies have demonstrated improvement...

pubmed.ncbi.nlm.nih.gov

 

[Jaybee00]

I’ll bet you could use oxybutynin maybe at double the dose over aroxybutynin (r enantiomer), and it would massively decrease the cost.