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A role for a leaky gut and the intestinal microbiota in the pathophysiology of ME/CFS Vipond 2019 PhD thesis

Discussion in 'ME/CFS research' started by Dolphin, Jul 19, 2019.

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  1. Dolphin

    Dolphin Senior Member (Voting Rights)

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    This research was funded or part funded by Invest in ME research

    https://ueaeprints.uea.ac.uk/70522/

     
    Last edited by a moderator: Jul 19, 2019
    Dolphin, Jul 19, 2019
    #1
    Legend, EzzieD, rvallee and 13 others like this.
  2. MeSci

    MeSci Senior Member (Voting Rights)

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    Oh dear - "postexternal malaise (PEM)"

    Hope it's right elsewhere in the document.
     
    MeSci, Jul 19, 2019
    #2
    Annamaria, mango, MEMarge and 2 others like this.
  3. Midnattsol

    Midnattsol Moderator Staff Member

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    I want transcriptome data from the gut of patients in PEM, to look at proteins involved with instestinal barrier function. It's not just bacteria that can affect this. And from my own experience when I've been very ill and had other cook for me (if I managed to eat) the diet has not always been gut microbiome friendly to say the least.. I haven't got the energy to read through this now (ironicly reading about leaky gut, diet and IBD for work), but how do they take this into account?
     
    Midnattsol, Jul 19, 2019
    #3
    Annamaria, Amw66 and DokaGirl like this.
  4. Barry

    Barry Senior Member (Voting Rights)

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    Have to hope this is a simple typo, and that is not really what they believe it is called! I wonder if someone can alert them to this.
     
    Barry, Jul 19, 2019
    #4
    Annamaria, MeSci and DokaGirl like this.
  5. DokaGirl

    DokaGirl Senior Member (Voting Rights)

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    Interesting, the concepts of a leaky gut and disordered gut bacteria used to be laughed at by allopathic medicine. Or, at least cause eye rolling. Now, this topic is getting more and more attention. Thank goodness!

    Just my own experiences, but there does seem to be a correlation between an increase in GI issues, and brain fog. When my GI problems/pain flare, the brain fog worsens. Too much fibre or carbs, can both cause GI problems to increase, which after experiencing this hundreds if not thousands of times over the decades, appears to lead directly to increased brain fog.

    During gradual onset, my IBS became much more painful.

    ETA: just added a bit more info.
     
    Last edited: Jul 19, 2019
    DokaGirl, Jul 19, 2019
    #5
    Saz94, sb4, Annamaria and 3 others like this.
  6. MEMarge

    MEMarge Senior Member (Voting Rights)

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    Hi @Andy, do you have an email for Quadram/Simon C?
     
    MEMarge, Jul 19, 2019
    #6
    Annamaria, Andy and MeSci like this.
  7. MeSci

    MeSci Senior Member (Voting Rights)

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    MeSci, Jul 19, 2019
    #7
    Annamaria, DokaGirl, MEMarge and 1 other person like this.
  8. Midnattsol

    Midnattsol Moderator Staff Member

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    There might be correlations between "leaky gut" and a more leaky blood-brain-barrier, that could perhaps cause brain-fog?
     
    Midnattsol, Jul 19, 2019
    #8
    Annamaria, Amw66, DokaGirl and 1 other person like this.
  9. Andy

    Andy Committee Member

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    Do you still need it?
     
    Andy, Jul 19, 2019
    #9
    DokaGirl likes this.
  10. MEMarge

    MEMarge Senior Member (Voting Rights)

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    No, I can email him. Thanks
     
    MEMarge, Jul 19, 2019
    #10
    DokaGirl, MeSci and Andy like this.
  11. MEMarge

    MEMarge Senior Member (Voting Rights)

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    @MeSci and @Andy
    Just got an email from Daniel V thanking us for pointing this out. He is contacting the UAE library to correct this and also going to have a read thro' the rest to check, now that he has a bit more time.

    Simon Carding's talk at IiMER covered his PhD. Hopefully, that will be out soon, as the Anne Ortegren memorial lecture is now on Youtube, hopefully the rest will follow.

    Daniel also said:

    "Part of this work, however, has been submitted for publication based on faecal metabolomics data and a targeted mass-spec analysis of bile acids. I hope this will be available soon. "
     
    MEMarge, Jul 19, 2019
    #11
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