Symptom Clusters in ME/CFS Reflect Distinct Neuroimmune and Autonomic Pathophysiological Mechanisms: A Translational Model
Habermann-Horstmeier, Lotte; Horstmeier, Lukas Maximilian
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Background
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating...
Effect of Metabolic Modulation on a Post-acute COVID-19 Vaccination Syndrome (PACVS) Cohort (ViTAL-SCAN19)
Brief Summary
The goal of this clinical trial is to evaluate whether metabolic modulation with a combined nutraceutical product can improve symptoms and metabolic health in adults...
Abstract
Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) can develop as post-vaccination syndrome (PVS) or Post-Acute Sequelae of SARS-CoV-2 infection (PASC). In our prior retrospective study, most patients with PVS who developed ME/CFS had vitamin D insufficiency or...
Outcomes of ME/CFS Following Infectious Mononucleosis: Seven-year Follow-up of a Prospective Study
Leonard A. Jason, Jacob Furst, Rebecca Worth, Ben Katz
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Background
Many individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) report experiencing an...
Microvascular Remodeling and Endothelial Dysfunction Across Post-COVID-19 and ME/CFS: Insights from the All Eyes on PCS Study
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Background
Post-viral diseases, including post-COVID-19 syndrome (PCS) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), cause...
Abstract
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and post-COVID-19 syndrome share a symptom profile, including severe fatigue, cognitive dysfunction, exertional intolerance, sleep disturbances, hypervigilance, and the paradoxical state of being “wired but tired.”
A...
See here for the abstract and links to the 2025 ME/CFS paper: link
See here for a link to a 2024 paper on covid-19 outcomes: link
(Development and evaluation of blood-based prognostic biomarkers for COVID disease outcomes using EpiSwitch 3-dimensional genomic regulatory immune-genetic...
Severe people may hold answers to Long COVID. They must be included in research.
After giving several examples of research projects that have included more severe patients, they made these comments:
Journal of Clinical Medicine: Special Issue
Deadline for manuscript submissions: 20 January 2026
Special Issue Information
Dear Colleagues,
Postural orthostatic tachycardia syndrome (POTS), myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID are complex syndromes caused...
Evaluating working memory functioning in individuals with myalgic encephalomyelitis/chronic fatigue syndrome: a systematic review and meta-analysis
Penson, Maddison; Kelly, Kate
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Abstract
Individuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)...
Hormonal alterations in adolescent chronic fatigue syndrome
Aim
The chronic fatigue syndrome is associated with alterations in the hypothalamus‐pituitary‐adrenal axis and cardiovascular autonomic nervous activity, suggesting a central dysregulation. This study explored differences among...
Down-regulation of renin–aldosterone and antidiuretic hormone systems in patients with myalgic encephalomyelitis/chronic fatigue syndrome
Miwa, Kunihisa
Background
Central nervous system dysfunction associated with myalgic encephalomyelitis (ME) has been postulated as the cause of chronic...
Distinct Symptom Clusters Reflect Pathophysiological Mechanisms in ME/CFS
Habermann-Horstmeier, Lotte; Horstmeier, Lukas M.
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Introduction
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe multisystemic disease with a broad spectrum of symptoms. A...
Evaluation of an online patient education program for children and young people with ME/CFS and their parents within the BAYNET FOR MECFS Study
Background:
ME/CFS (Myalgic Encephalomyelitis/Chronic Fatigue Syndrome) poses challenges for affected children and...
An article from The Sick Times explaining why telehealth (remote/virtual healthcare) is needed by patients with Long Covid, ME/CFS, and other chronic illness or disabilities. The article lists some actions that people in the USA and Canada can take to advocate for telehealth.
Telehealth is...
Connecting the Dots Between ME/CFS, HSD/hEDS, Abnormal Fascia, Lymphatic and Glymphatic System Impairment, and Craniocervical Instability
Lubell, Jeffrey
Abstract
This hypothesis paper encourages a comprehensive approach to studying Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)...
Heightened prevalence of chronic fatigue syndrome in U.S. sexual minorities
Purpose
To assess the prevalence and odds of chronic fatigue syndrome (CFS) among lesbian, gay, bisexual, and other sexual minority individuals (LGB+) in the United States using a multi-year, nationally representative...
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