A Thought Experiment on Muscles

Have another hot cross bun and an extra large glass of lemonade?

Well it’s all wonderfully confusing and interesting.

 

yes me too

it certainly is, I'm not keeping up with the thread never mind all the science on it, but I'm fascinated by it all even if i dont understand most of it. And its just so heartening to be reminded that so many brght minds are working on it! When i get so low i want to give up, i remind myself of this, & it gives me hope!

 

All this talk of afferent nerves & the spinal column... apologies if this is idiotic & totally unconnected scientifically but i wonder about the post mortem dorsal root ganglionitis findings & whether they have any connection or anything relevant to tell us?

I know the DRG are not part of the spinal chord, but arent they involved in sensory input/signalling too?

 

Absolutely, they are where the primary afferent neuron cell bodies are, with axons carrying on up the cord. So yes, I agree that the observations on DRG could be very important.

I recently went to a lecture on people who cannot feel pain and there is one form of the disease due to a genetic error in a gene that encodes for a long non-coding RNA that controls development of these cells. That would not be directly relevant to ME/CFS but it made me wonder whether in ME/CFS these cells are being changed by signals like LNC-RNAs that we wouldn't see or measure normally. `maybe only in very severe cases there might be a local cellular response of 'ganglionitis'.