The drug has been used with some success to treat a similar complex, post-infectious syndrome marked by cognitive deficits and overwhelming fatigue called myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Drawing on its use in ME/CFS and a handful of long COVID pilot studies, there are now at least four clinical trials planned to test naltrexone in hundreds of patients with long COVID, according to a Reuters review of Clinicaltrials.gov and interviews with 12 ME/CFS and long COVID researchers. https://www.reuters.com/business/he...ting-long-covid-brain-fog-fatigue-2022-10-18/
I can only see two studies on Clinicaltrials.gov that aren't withddrawn: Pilot Study Into LDN and NAD+ for Treatment of Patients With Post-COVID-19 Syndrome Uncontrolled, unblinded. Yawn. Low-dose Naltrexone for Post-COVID Fatigue Syndrome Double-blinded, 80 in each arm (LDN and placebo). Phase 2 study in Canada. Looking good.
Given how its gone with ME/CFS patients who have tried it so far I don't imagine it will be very successful for most people.
I tried low-dose naltrexone (LDN) for m.e. for a month, but had constant nausea and several episodes of prolonged severe nausea, vomiting, delayed gastric emptying, sweating, diarrhea, and worse IBS. In one episode, I needed to vomit for about 7 hours but could not. Strange regurgitating. When finally vomited, was a large amount. This is the first time I had gastroparesis. In 2016 (a few years later) I was diagnosed with Gastroparesis (See file median-other--a.org). It continues. Thus, LDN seems to have caused gastroparesis. Recovery from the physical stress of having to kneel due to nausea was months or longer, possibly permanent. I am bedridden and must be supine. I have low level nausea most of the time. No anti-nausea works (See file median-other--a.org) for any type of nausea except that metoclopramide (generic Reglan) helps severe gastroparesis. I used a compounding pharmacy, who were given strict instructions to use pure LDN plus acidophilus filler, immediate release. Not crushed tablets. However, they admitted later that they used crushed tablets. I do not know whether the reactions were caused by the crushed tablets or by LDN itself. I take strong measures to prevent gastroparesis including lying on left side for many hours, food-processed food.
