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Alcohol Intolerance poll. Please do the poll even if your answer is no.

Discussion in 'Hypersensitivity and Intolerance Reactions' started by Jonathan Edwards, Oct 30, 2024.

?

Have you had alcohol intolerance with ME/CFS and what sort?

  1. No

    13 vote(s)
    10.7%

  2. Worsened 'hangover' effect the next day

    37 vote(s)
    30.6%

  3. The taste became unpleasant

    7 vote(s)
    5.8%

  4. Just 'put off' - I don't feel like having it

    21 vote(s)
    17.4%

  5. Upset stomach - soon after

    12 vote(s)
    9.9%

  6. Aggravation of ME/CFS symptoms soon after

    60 vote(s)
    49.6%

  7. Pains elsewhere

    9 vote(s)
    7.4%

  8. Other unpleasant symptoms

    55 vote(s)
    45.5%

  9. I've been avoiding alcohol for so long now that I can't remember the symptoms that led me to avoid

    18 vote(s)
    14.9%
Multiple votes are allowed.
Page 10 of 10
  1. Hutan

    Hutan Moderator Staff Member

    Messages:
    29,374
    Location:
    Aotearoa New Zealand
    More on that, the rabbit study above reported the endothelin-1 synthesis is decreased by alcohol.

    About endothelin-1:
    There is a bit of evidence that endothelin-1 is increased in ME/CFS e.g. in two studies by different teams:

    What if over-production of endothelin-1 in ME/CFS was an adaptation to poor control of blood vessels because the peripheral vascular nerves aren't working properly? (or maybe a deficiency of effective endothelin-1 receptors?) And what if alcohol stopped that adaptative increased endothelin-1, resulting in even worse vasodilation and lack of a constrictive response?
     
    Last edited: Nov 6, 2024
    Hutan, Nov 6, 2024
    #181
    AliceLily, wigglethemouse, hotblack and 3 others like this.
  2. Starrynight

    Starrynight Established Member

    Messages:
    4
    I think this is a really interesting question. However the poll doesn't seem to have a box which corresponds to the best description of the reaction I have WHEN severely alcohol intolerant. In that case for me it is like rapidly feeling "poisoned" or more specifically the Disulfiram + alcohol reaction as I have understood it from reading descriptions (I don't have personal experience of that medication). This never happened to me prior to ME/CFS

    The really confounding thing is that this comes and goes and doesn't necessarily correlate with severity in my case. When I am intolerant it is bad enough for me to give up alcoholic drinks for several years, which I have done and then found, perhaps by chance, that I can tolerate some and go back to drinking a bit for several years. Until it comes back...!
     
    Starrynight, Nov 6, 2024
    #182
    AliceLily, hotblack, MeSci and 5 others like this.
  3. Haveyoutriedyoga

    Haveyoutriedyoga Senior Member (Voting Rights)

    Messages:
    860
    Location:
    South West, UK
    Yes it’s odd how it comes and goes isn’t it!
     
    Haveyoutriedyoga, Nov 6, 2024
    #183
    AliceLily, hotblack, MeSci and 6 others like this.
  4. Sean

    Sean Moderator Staff Member

    Messages:
    8,064
    Location:
    Australia
    Important variable.

    Sometimes a drink or two can be fine, at least at the time of drinking. It has the normal expected pleasant effects. At other times it feels unpleasant pretty quickly, within maybe 10 min. The 'poisoned' sensation, as it were.
     
    Sean, Nov 7, 2024
    #184
    AliceLily, bobbler and hotblack like this.
  5. hotblack

    hotblack Senior Member (Voting Rights)

    Messages:
    347
    Location:
    UK
    Interesting that there are people talking of a variable response. Not something those of us who don’t drink can attest to but I guess it’s possible we’d see the same. The talk of experiments ‘for science’ becomes more appealing!

    I’m interested in how vascular nerves could fit in and wonder about correlation with other nerve problems often mentioned (peripheral neuropathy, small fibre neuropathy). And the studies which have shown endothelial dysfunction of some sort.

    Difficult to survey the latter but maybe we can get an idea of prevalence of the former from people here?
     
    hotblack, Nov 7, 2024
    #185
    AliceLily likes this.
Page 10 of 10

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