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Alterations in T and B cell function persist in convalescent COVID-19 patients, 2021, Shuwa et al

Discussion in 'Epidemics (including Covid-19)' started by Andy, Apr 7, 2021.

  1. Andy

    Andy Committee Member & Outreach

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    Highlights
    1. Lymphocytes were examined during COVID-19 and at up to 6 months of convalescence

    2. B cell changes seen during acute COVID-19 were largely restored in convalescence

    3. T cells from convalescent COVID-19 patients displayed persistent changes

    4. Lymphocyte signatures defined 3 convalescent patient groups; one with poorer outcome

    Summary

    Background
    Emerging studies indicate that some COVID-19 patients suffer from persistent symptoms including breathlessness and chronic fatigue; however the long-term immune response in these patients presently remains ill-defined.

    Methods
    Here we describe the phenotypic and functional characteristics of B and T cells in hospitalised COVID-19 patients during acute disease and at 3-6 months of convalescence.

    Findings
    We report that the alterations in B cell subsets observed in acute COVID-19 patients were largely recovered in convalescent patients. In contrast, T cells from convalescent patients displayed continued alterations with persistence of a cytotoxic programme evident in CD8+ T cells as well as elevated production of type-1 cytokines and IL-17. Interestingly, B cells from patients with acute COVID-19 displayed an IL-6/IL-10 cytokine imbalance in response to toll-like receptor activation, skewed towards a pro-inflammatory phenotype. Whereas the frequency of IL-6+ B cells was restored in convalescent patients irrespective of clinical outcome, recovery of IL-10+ B cells was associated with resolution of lung pathology.

    Conclusions
    Our data detail lymphocyte alterations in previously hospitalized COVID-19 patients up to 6 months following hospital discharge and identify 3 subgroups of convalescent patients based on distinct lymphocyte phenotypes, with one subgroup associated with poorer clinical outcome. We propose that alterations in B and T cell function following hospitalisation with COVID-19 could impact longer term immunity and contribute to some persistent symptoms observed in convalescent COVID-19 patients.

    Open access, https://www.sciencedirect.com/science/article/pii/S266663402100115X
     
    Ariel, alktipping, DokaGirl and 5 others like this.

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