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An Hour of Light and Sound a Day Might Keep Alzheimer’s at Bay

Discussion in 'Health News and Research unrelated to ME/CFS' started by Alvin, Mar 17, 2019.

  1. Alvin

    Alvin Senior Member (Voting Rights)

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    https://www.scientificamerican.com/...and-sound-a-day-might-keep-alzheimers-at-bay/
     
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  2. roller*

    roller* Senior Member (Voting Rights)

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    40 hz is called "Gamma Band" (Neural Stimulation)
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130417/



    5 - 9 Hz - brown note


    30 hz - parkinson
    https://www.apa.org/monitor/2013/11/music
    https://www.ncbi.nlm.nih.gov/pubmed/20037223



    40 hz - alzheimers
    https://www.apa.org/monitor/2013/11/music
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141741/



    432 Hz - frequency of the universe
    https://ask.audio/articles/music-theory-432-hz-tuning-separating-fact-from-fiction




    [​IMG]
     
    Last edited: Mar 17, 2019
    hedgehog, rvallee and Alvin like this.
  3. roller*

    roller* Senior Member (Voting Rights)

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    ... external stimuli ...vestibular system ... ?
    does this frequency "loss" have something to do with unexplained hearing loss ?

    after googling it seems a stupid question: would it be possible to display the hz-frequencies in youtube-music ?
     
  4. roller*

    roller* Senior Member (Voting Rights)

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    Accelerated Learning | Gamma Waves for Focus, Concentration, Memory | Monaural Beats | Focus Music
    40 Hz Gamma Monaural Beats



    40hz per second flashing Alzheimer's disease light therapy
     
  5. roller*

    roller* Senior Member (Voting Rights)

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    to find out if you can hear 40 hz at all ...

    ... perhaps some AD patients may not hear much at those low frequencies, and thats why they use flickering LIGHT-40hz to activate it?

    wondering, if 40hz-light-flicker-therapy may restore a neurosenso-hearing-fail at 40hz... ?

    on youtube they have a range of test tone videos https://www.youtube.com/playlist?list=PLzFvCAfIq7a2SIBfDhpCytfJ4RHVb_KLY
     
  6. Wonko

    Wonko Senior Member (Voting Rights)

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    Anybody got a device capable of playing back 40Hz video as intended? My Tv or monitor can't, they weren't designed to - 50Hz to 120Hz is what they were designed for, with the odd trip down to 24Hz in the case of the TV - but 40Hz? - what is the point of having that on youtube?
     
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  7. roller*

    roller* Senior Member (Voting Rights)

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    @Wonko you think, 40hz lights on youtube are not played on the laptop with 40hz ?

    im searching for a light bulb with this flicker frequency ... "light therapy", possibly
     
  8. Wonko

    Wonko Senior Member (Voting Rights)

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    How could a 50Hz device accurately display 40Hz without generating an interference pattern of some sort? Even if that's suppressed the result wouldn't be a 40Hz flicker but some hybrid.

    I may or course be wrong, but several years ago I spent a fair amount of time, effort and money trying to get around a similar problem, using conventional equipment, that was causing rendering/playback issues.

    Just coz the source is fine, and the playback device can handle it, doesn't mean the renderer can (in this case a monitor/TV).

    ETA - 40Hz sound is incredibly annoying, and the video, yes it has interference when played back on my 50Hz TV, or even at 60Hz - it might be okay at 80Hz but I can't seem to do that, 79Hz is the closest to 80Hz I can get.

    I now have a mild headache, from under 20 seconds of exposure to the video. Not complaining, just something for others to be aware of.
     
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  9. roller*

    roller* Senior Member (Voting Rights)

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    sorry to hear ;) @Wonko

    i dont know what it sounds or may cause since i dont hear anything at 40hz

    im "moderate neurosensory hearing loss"
     
  10. Wonko

    Wonko Senior Member (Voting Rights)

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    It sounds a bit like a swarm of insects if you've ever heard one of them, possibly on a nature program or horror film. Just deeper and quieter. No idea why it's annoying but it was.
     
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  11. roller*

    roller* Senior Member (Voting Rights)

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    sounds like my "tinnitus"-thing... :)

    there is another interesting article, how they found out about AD-frequency (2018)
    https://www.nature.com/articles/d41586-018-02391-6

    but .. the engineered AD mice are not perfect matches to human AD (though, it seems the frequencies indeed help in humans)
    and "Gamma oscillations are the type most likely to induce seizures in people with photosensitive epilepsy"
    and amiloid is produced for protection i understand, so it may make sense that its there (the lesser evil, sort of)
     
  12. Forbin

    Forbin Senior Member (Voting Rights)

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    When I first read this, I took "bathing" literally. :)
     
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  13. akrasia

    akrasia Established Member (Voting Rights)

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    I’ve been following Cognito Therapeutics for a couple of years, waiting to hear more about the progress of its Gamma 40 hz study on human subjects with Alzheimer’s. Well, it seems they have appointed a new CEO, which portends good developments are on the horizon.

    (Cognito Therapeutics was set up in the wake of the striking results of the mouse studies that showed reductions in beta amyloid, tau, and stimulation of the microglia in the brain. Its primary purpose is to bring to market a sound /light device that can reliably deliver the 40hz gamma frequency to human ears and eyes. The study organized by Li Huei Tsai started last summer and will last until summer 2021)

    https://www.businesswire.com/news/home/20201209005339/en/Cognito-Therapeutics-
    Appoints-Industry-Pioneer-Brent-Vaughan-as-Chief-Executive-Officer



    This summer of 2020 article gives an extended overview of the state of play in 40hz light/sound treatments:

    https://www.pnas.org/content/117/31/18142

    The first link below requires only a registration. While some of it seemed opaque to this humanities brain, it’s aimed at a general audience, and was very lucid and compelling, so in contrast to the turbid muck we have to so often engage. It’s Li Huei Tsai speaking and lasts about an hour.

    https://www.technologynetworks.com/...rain-waves-to-fight-alzheimers-disease-329617

    For a much shorter version there’s a 4 minute film clip on the NIH site.
    https://www.nia.nih.gov/news/noninv...ces-alzheimers-pathology-improves-memory-mice

    Li Huei Tsai is quoted in the PNAS article as already considering autism, schizophrenia, as well as other neuro degenerative diseases as potential targets for studies. If this holds up it is a remarkable moment for medicine.
     
  14. akrasia

    akrasia Established Member (Voting Rights)

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  15. akrasia

    akrasia Established Member (Voting Rights)

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    https://www.businesswire.com/news/h...mer’s-Disease-at-2021-ADPD-Virtual-Conference


    Cognito Therapeutics to Announce New Clinical Data Evaluating Gamma Frequency Neuromodulation to Treat Alzheimer’s Disease at 2021 AD/PD Virtual Conference

    March 02, 2021 08:00 AM Eastern Standard Time


    CAMBRIDGE, Mass.--(BUSINESS WIRE)--Cognito Therapeutics, a clinical-stage company leading the development of a new class of disease-modifying digital therapeutics to treat neurodegenerative disorders, announced today it will present for the first time, new clinical data for its digital therapeutic utilizing gamma frequency neuromodulation in Alzheimer’s Disease, at the 15th International Conference on Alzheimer's and Parkinson's Diseases (AD/PD), held virtually March 9-14, 2021.

    Details of the symposium panel are below:

    Symposium title: Gamma sensory stimulation, a novel AD therapeutic intervention: initial safety, efficacy and biomarker changes from two prospective clinical studies

    Date/Time:

    Friday, March 12, 10:00 – 11:00 am ET, followed by Live Q&A

    Moderator:

    Dr. Li-Huei Tsai, neuroscientist and the Director of the Picower Institute for Learning and Memory in the Department of Brain and Cognitive Sciences at MIT

    Panelists:

    Dr. James Lah, Principal Investigator of the Flicker study, and Director of the Cognitive Neurology Program, Emory University

    Dr. Tom Megerian, Chief Medical Officer, Cognito Therapeutics

    Dr. Suzanne Hendrix, CEO, Pentara Corporation

    A replay of the symposium panel will be posted on Cognito’s website at www.cognitotx.com.
     
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  16. Wonko

    Wonko Senior Member (Voting Rights)

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    I've just re-read this thread and come to the conclusion that the hypothesis makes absolutely no sense, at least to me.

    What is the proposed mechanism? Why 40 hz and not 39.996734hz?

    Given that processing in the visual and auditory systems does not run at the same speed, or with the same 'integrity' (most of what we see, and hear, is entirely fictional, a best guess, to cut processing time and load - or so I am told) why use the same frequency for both input methods?

    and bits about the 'frequency of the universe' - erm....sounds like something that might not be....100% accurate in the context of anything else but the alleged frequency fo the universe (and has anyone checked that number, everywhere (including places with no matter), at every speed?).
     
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  17. Kitty

    Kitty Senior Member (Voting Rights)

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    Yep.

    It's 42.
     
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