Open Analysis of Post-exertional Malaise Using a Two-day CPET in People With ME/CFS

John Mac

John Mac

Senior Member (Voting Rights)
Sponsor:
Ithaca College

Collaborators:
Cornell University
Weill Cornell Medicine
Workwell Foundation

Information provided by (Responsible Party):
Ithaca College

Brief Summary:
This study aims to collect and identify key outcome measures or disease parameters in ME/CFS that are altered during elevated symptoms relative to baseline by gathering information before and after symptom provocation using a two-day cardiopulmonary exercise test.

Condition or disease Intervention/treatment Phase
Myalgic EncephalomyelitisChronic Fatigue Syndrome Other: Two-day cardiopulmonary exercise test Not Applicable

Detailed Description:
The phenomenon of post-exertional malaise (PEM), in which an ME/CFS patient's symptoms are elevated following even low-level exertion, is a hallmark feature of the disease. The cause of PEM, like the cause of ME/CFS, is not understood. This study aims to utilize a two-day CPET to invoke PEM. This provides a unique opportunity to collect data on how key outcome measures or disease parameters are altered during elevated symptoms relative to baseline within each patient by gathering information before and after symptom provocation.

A total of 90 participants and 90 controls will undergo CPET testing. Participation will be split amongst three different sites (Ithaca, NY, New York, NY, and Los Angeles, CA). Subjects will be located in urban and rural areas to establish relatively diverse study populations.

This study is a component of the Cornell ME/CFS Collaborative Research Center (CRC). Blood samples taken before and after CPET will be utilized in associated projects with the Cornell ME/CFS CRC. CPET data along with the analysis of blood samples has great potential to reveal why exercise negatively affects ME/CFS patients and thus perhaps why patients are also impaired even before increasing their activity level.
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https://clinicaltrials.gov/ct2/show/NCT04026425
 
Just to make this extra clear:
They are currently recruiting for this study at 3 sites: "Participation will be split amongst three different sites (Ithaca, NY, New York, NY, and Los Angeles, CA)".

Looking for ME/CFS patients as well as non-active healthy controls.
 
Workwell just highlighted this on their mailing list
Workwell email said:
We are currently looking for people with ME/CFS and health control subjects to participate in the NIH-funded Cornell University Collaborative Research Center study of ME/CFS.

If you are a person with ME/CFS or have a family member or friend that is willing to participate as a healthy, inactive control, please contact us!

For additional information, visit Workwell Foundation or Cornell's Center for Enervating NeuroImmune Disease
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By Maria Russell, September 7, 2021
MEN & WOMEN! Learn your fitness level and more. We need ‘LOW or NO-ACTIVE’ volunteers for our study.
We are recruiting healthy, low/in-active volunteers for a study of exercise capacity at Ithaca College. Participants will serve as controls for a grant funded study of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS). You will get a report of your exercise test results which will include information about your aerobic fitness level, other health measures, and baseline data for starting an exercise program if you are interested in doing so.

Who is eligible?

Healthy, low/in-active volunteers between 25 – 65 years

Who is NOT eligible?
Smoker, or stopped smoking less than 1 year ago - Pregnant or breast feeding - Diabetic - Have a metabolic, cardiovascular and/or neuro-immune disease - Have an orthopedic limitation that prohibits stationary cycle exercise

What must you do?
Have a short phone conversation to determine eligibility. - If eligible, first meet remotely with our physician for clearance to participate in the study, then meet with the physician on-campus for a brief physical exam. During the on-campus meeting, urine and a small blood sample will be collected. You will not be charged any fee to be examined by our physician or for the blood and urine tests.

- Complete questionnaires about your health/medical history and physical activity level - Complete 2 exercise tests on a stationary cycle separated by 24 hours. Each test requires 8-12 minutes of exercise. Blood will be collected before and after each exercise test. - You must stop taking all vitamin/mineral supplements, CBD products and marijuana for 2 weeks before the first exercise test, but can resume taking them after the 2nd exercise test.

The total time commitment for participation in this research study is about 5 hours. You will receive $300 for your time and contribution.
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https://www.ithaca.edu/intercom/202...we-need-low-or-no-active-volunteers-our-study
 
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