Anti-stress effects of human placenta extract: possible involvement of the oxidative stress system in rats, 2018, Shim et al

Andy · May 12, 2018

This looks familiar but a forum search didn't turn up anything. In my opinion, this barely counts as biomed ME research but it doesn't really fit elsewhere.

Abstract
Background

Human placenta hydrolysate (hPH) has been utilized to improve menopausal, fatigue, liver function. Its high concentration of bioactive substances is known to produce including antioxidant, anti-inflammatory and anti-nociceptive activities. However, its mechanisms of stress-induced depression remain unknown.

Methods
The present study examined the effect of hPH on stress-induced depressive behaviors and biochemical parameters in rats. hPH (0.02 ml, 0.2 ml or 1 ml/rat) was injected intravenously 30 min before the daily stress session in male Sprague-Dawley rats exposed to repeated immobilization stress (4 h/day for 7 days). The depressive-like behaviors of all groups were measured by elevated plus maze (EPM) and forced swimming test (FST). After the behavior tests, brain samples of all groups were collected for the analysis of glutathione peroxidase (GPx) and nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) staining.

Results
Treatment with hPH produced a significant decrease of immobility time in the FST compared to the controls. Additionally, hPH treatment elicited a slightly decreasing trend in anxiety behavior on the EPM. Furthermore, hPH increased the level of GPx protein in the hippocampus, and decreased the expression of NADPH-d in the paraventricular nucleus (PVN).

Conclusion
This study demonstrated that hPH has anti-stress effects via the regulation of nitric oxide (NO) synthase and antioxidant activity in the brain. These results suggest that hPH may be useful in the treatment of stress-related diseases such as chronic fatigue syndrome.
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Open access at https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-018-2193-x

Esther12 · May 12, 2018

I've got some prejudices that discourage me from reading this.

Invisible Woman · May 12, 2018

These results suggest that hPH may be useful in the treatment of stress-related diseases such as chronic fatigue syndrome.
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Bolding mine.

Is ME or CFS any more stress related than MS or rheumatoid arthritis or lots of other illnesses? Cause I don't think so.

Any actual proof from any actual rigorous research?

adambeyoncelowe · May 13, 2018

Invisible Woman said: ↑

Bolding mine.

Is ME or CFS any more stress related than MS or rheumatoid arthritis or lots of other illnesses? Cause I don't think so.

Any actual proof from any actual rigorous research?
Click to expand...

Newton's study (posted on here today) suggests the opposite!

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Anti-stress effects of human placenta extract: possible involvement of the oxidative stress system in rats, 2018, Shim et al

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Anti-stress effects of human placenta extract: possible involvement of the oxidative stress system in rats, 2018, Shim et al

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