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Review Attenuating Post-exertional Malaise in [ME/CFS] and Long-COVID: Is Blood Lactate Monitoring the Answer? 2024 Faghy et al

Discussion in 'ME/CFS research' started by Andy, Apr 2, 2024.

  1. Andy

    Andy Committee Member

    Hampshire, UK
    • Lactate monitoring has the potential to extend beyond applied sports settings and could be used to monitor the physiologic and pathophysiological responses to external and internal stimuli in chronic disease areas such as Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Post-Covid syndrome or Long Covid.

    • It is applicable due to the recurrent, episodic and often disabling post-exertional symptom exacerbation (PESE) otherwise referred to as post-exertional malaise (PEM) which is a characteristic symptom of ME/CFS and Long Covid that can last for days and/or weeks.

    • Lactate monitoring presents an opportunity to support those living with ME/CFS and Long COVID, by allowing patients and practitioners to determine the intensity and anaerobic contribution to everyday tasks which could aid the development of pacing strategies that prevent PEM/PESE.
    No further abstract available.

    Paywall, https://www.sciencedirect.com/science/article/abs/pii/S0146280624001932
    sebaaa, Hutan, Kitty and 7 others like this.
  2. Creekside

    Creekside Senior Member (Voting Rights)

    That sounds like another "Here's an easy test that probably has nothing to do with the disease, but which we can get research funding for because it sounds good."
    RedFox, Sean, alktipping and 3 others like this.
  3. Dolphin

    Dolphin Senior Member (Voting Rights)

    Last edited: Apr 3, 2024
  4. bobbler

    bobbler Senior Member (Voting Rights)

    Maybe, but he does seem to be looking at this from a good number of angles. I'm reticent to without a thorough dive through everything sign off someone as thumbs up but at least his lists of references aren't 'limited'.

    He mentions that these portable monitors now being readily available has indeed made this possible and are used by athletes etc (he references a paper from 2010 that reviews some of these) so I guess as long as he is impartial when assessing whether it is a useful additional context then it is indeed something begging to be looked into. Interesting given his focus seems to have been coming from the covid, then long covid direction, that this is looked at ME/CFS directly here.
    Mij, Sean, Kitty and 3 others like this.
  5. SNT Gatchaman

    SNT Gatchaman Senior Member (Voting Rights)

    Aotearoa New Zealand
    The pre-proof will need to correct any ME/CSF typos. It's a short opinion piece —

    MEMarge, Mij, Dolphin and 3 others like this.
  6. EndME

    EndME Senior Member (Voting Rights)

    Is Blood Lactate Monitoring the Answer for any other health problems and do those have anything in common with ME/CFS?

    Continous Blood Lactate Monitors are currently a big hype in sports, especially cycling, albeit these devices basically not even existing yet and their scientific accuracy currently being questionable.
    RedFox, Joan Crawford, Kitty and 6 others like this.
  7. Trish

    Trish Moderator Staff Member

    The article is now open access. I think it looks like an interesting idea, though before recommending it for individuals to assist with pacing, research needs to be done on patterns of lactate levels in ME/CFS and how they relate to activity when compared to healthy sedentary controls. If it does indeed show a clear pattern of difference, it might be useful both for self monitoring and as an objective outcome measure in treatment trials. But it seems like there's a lot more research needed before that happens.
    Grigor, MEMarge, RedFox and 6 others like this.
  8. Mij

    Mij Senior Member (Voting Rights)

    I am also interested in learning about lactate levels in the brain and how they negatively interplay with cognitive and physical activities.
  9. poetinsf

    poetinsf Senior Member (Voting Rights)

    Western US
    If lactate level in MECFS is any different, it would've been known long time ago, I would think. It should be just a matter of drawing blood every hour after the exertion and plot the time series, like they do in sports medicine with athletes.
    Sean likes this.
  10. Creekside

    Creekside Senior Member (Voting Rights)

    It might be detectable by MRI too. Maybe not though. I recently read about a new MRI with 11.7 Tesla, which among other improvements, allows detection of molecules that don't show a strong enough signal in weaker fields. I also read about a new technique using a virus that produces a certain enzyme in astrocytes, making them glow in response to oxygen levels. A similar technique might be developed for detecting other molecules. Lots of new tools and techniques. I wish researchers would use them properly to study ME, rather than just repeat the same old experiments trying to get better-looking results.
    Sean and poetinsf like this.
  11. Eddie

    Eddie Senior Member (Voting Rights)

  12. Sean

    Sean Moderator Staff Member

    Lactate might not be a useful measure for revealing pathology in ME, but there are likely to be a range of relatively simple measures that could be useful for helping to guide activity levels (pace) and avoid getting too deep into PEM.

    Whether lactate is one of those, in principle and practically, is another story.
    Mij, Dolphin and Trish like this.

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