Review Beyond acute infection: mechanisms underlying post‐acute sequelae of COVID‐19 (PASC) 2024 Adhikari et al

Anurag Adhikari, Janesha Maddumage, Emily M Eriksson, Sarah J Annesley, Victoria A Lawson, Vanessa L Bryant and Stephanie Gras
Med J Aust 2024; 221 (9): S40-S48. || doi: 10.5694/mja2.52456
Published online: 4 November 2024

https://www.mja.com.au/journal/2024...-underlying-post-acute-sequelae-covid-19-pasc

Summary

• Immune dysregulation is a key aspect of post‐acute sequelae of coronavirus disease 2019 (PASC), also known as long COVID, with sustained activation of immune cells, T cell exhaustion, skewed B cell profiles, and disrupted immune communication thereby resulting in autoimmune‐related complications.
• The gut is emerging as a critical link between microbiota, metabolism and overall dysfunction, potentially sharing similarities with other chronic fatigue conditions and PASC.
• Immunothrombosis and neurological signalling dysfunction emphasise the complex interplay between the immune system, blood clotting, and the central nervous system in the context of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection.
• Clear research gaps in the design of PASC studies, especially in the context of longitudinal research, stand out as significant areas of concern.

 

Have yet to find this study on S4ME

The referenced article https://www.mdpi.com/2075-1729/11/9/986, discusses endothelial-1 but makes no mention of ME/CFS or having done a study! That is curious.

edited to add info

 

It does not seem to be a study of ME/CFS or LC. Maybe they have cited the wrong paper.

 

Perhaps they meant to cite this one:

https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-022-03346-2

 

Good score thanks! yes, that has been discussed on S4ME https://www.s4me.info/threads/endot...me-cfs-haffke-scheibenbogen-et-al-2022.25093/