Review Beyond acute infection: mechanisms underlying post‐acute sequelae of COVID‐19 (PASC) 2024 Adhikari et al

[hibiscuswahine]

Anurag Adhikari, Janesha Maddumage, Emily M Eriksson, Sarah J Annesley, Victoria A Lawson, Vanessa L Bryant and Stephanie Gras
Med J Aust 2024; 221 (9): S40-S48. || doi: 10.5694/mja2.52456
Published online: 4 November 2024

https://www.mja.com.au/journal/2024...-underlying-post-acute-sequelae-covid-19-pasc

Summary

• Immune dysregulation is a key aspect of post‐acute sequelae of coronavirus disease 2019 (PASC), also known as long COVID, with sustained activation of immune cells, T cell exhaustion, skewed B cell profiles, and disrupted immune communication thereby resulting in autoimmune‐related complications.
• The gut is emerging as a critical link between microbiota, metabolism and overall dysfunction, potentially sharing similarities with other chronic fatigue conditions and PASC.
• Immunothrombosis and neurological signalling dysfunction emphasise the complex interplay between the immune system, blood clotting, and the central nervous system in the context of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection.
• Clear research gaps in the design of PASC studies, especially in the context of longitudinal research, stand out as significant areas of concern.

 

[hibiscuswahine]

A comprehensive study revealed that endothelial dysfunction independently stands as a risk factor for PASC where endothelial biomarkers such as endothelin 1 (ET‐1) were significantly higher in both patients with ME/CFS and patients with PASC compared with healthy donors.58 /QUOTE]

This study is referenced as

• 58. Kostov K. The causal relationship between endothelin‐1 and hypertension: focusing on endothelial dysfunction, arterial stiffness, vascular remodeling, and blood pressure regulation. Life (Basel) 2021; 11: 986.

/QUOTE]

Have yet to find this study on S4ME

The referenced article https://www.mdpi.com/2075-1729/11/9/986, discusses endothelial-1 but makes no mention of ME/CFS or having done a study! That is curious.

edited to add info

 

[Jonathan Edwards]

Have yet to find this article on S4ME.

It does not seem to be a study of ME/CFS or LC. Maybe they have cited the wrong paper.

 

[Nightsong]

The referenced article https://www.mdpi.com/2075-1729/11/9/986, discusses endothelial-1 but makes no mention of ME/CFS or having done a study! That is curious.

Perhaps they meant to cite this one:

https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-022-03346-2

 

[hibiscuswahine]

Perhaps they meant to cite this one:

https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-022-03346-2

Good score thanks! yes, that has been discussed on S4ME https://www.s4me.info/threads/endot...me-cfs-haffke-scheibenbogen-et-al-2022.25093/