Bile Acid Signaling in Neurodegenerative and Neurological Disorders, 2020, Grant and DeMorrow

Andy · Aug 23, 2020

Bile acids are commonly known as digestive agents for lipids. The mechanisms of bile acids in the gastrointestinal track during normal physiological conditions as well as hepatic and cholestatic diseases have been well studied. Bile acids additionally serve as ligands for signaling molecules such as nuclear receptor Farnesoid X receptor and membrane-bound receptors, Takeda G-protein-coupled bile acid receptor and sphingosine-1-phosphate receptor 2.

Recent studies have shown that bile acid signaling may also have a prevalent role in the central nervous system. Some bile acids, such as tauroursodeoxycholic acid and ursodeoxycholic acid, have shown neuroprotective potential in experimental animal models and clinical studies of many neurological conditions. Alterations in bile acid metabolism have been discovered as potential biomarkers for prognosis tools as well as the expression of various bile acid receptors in multiple neurological ailments. This review explores the findings of recent studies highlighting bile acid-mediated therapies and bile acid-mediated signaling and the roles they play in neurodegenerative and neurological diseases.
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Open access, https://www.mdpi.com/1422-0067/21/17/5982/htm

adambeyoncelowe · Aug 23, 2020

@mariovitali One for you, perhaps?

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Bile Acid Signaling in Neurodegenerative and Neurological Disorders, 2020, Grant and DeMorrow

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Bile Acid Signaling in Neurodegenerative and Neurological Disorders, 2020, Grant and DeMorrow

Andy Committee Member

adambeyoncelowe Senior Member (Voting Rights)

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