bile acid

  1. Chandelier

    Preprint Multiomic and Spatial Profiling of Colorectal Tissue Reveals Viral Persistence and Immune Dysregulation in Long COVID, 2026, LaFranchi et al.

    Multiomic and Spatial Profiling of Colorectal Tissue Reveals Viral Persistence and Immune Dysregulation in Long COVID Abstract Long COVID (LC) - a chronic condition characterized by persistent, debilitating symptoms following SARS-CoV-2 infection - has emerged as a major public health...
  2. SNT Gatchaman

    Preprint Peripheral metabolic signatures in patients with neuropsychiatric long COVID syndrome, 2026, Bergmann et al.

    Peripheral metabolic signatures in patients with neuropsychiatric long COVID syndrome Neuropsychiatric symptoms are considered the most common feature of long COVID disease. Recent studies have demonstrated structural brain changes and highlighted the importance of neuroinflammation in the...
    • SNT Gatchaman
    • Thread
    • acylcarnitine bile acid cortical thickness lipid metabolism mri sphingosine-1-phosphate
    • Replies: 5
    • Forum: Long Covid research
  3. Dolphin

    Cross-definition GWAS of IBS in 2.8 million individuals reveals cardiometabolic and triglyceride-linked mechanisms, 2026, Di Lorenzo

    https://gut.bmj.com/content/early/2026/07/01/gutjnl-2026-338800 PDF Neurogastroenterology Original research Cross-definition GWAS of IBS in 2.8 million individuals reveals cardiometabolic and triglyceride-linked mechanisms Abstract Background Irritable bowel syndrome (IBS) is a complex...
  4. Sean

    Genetic dissection of stool frequency implicates [B1] and other actionable pathways in the modulation of gut motility, 2026, Díaz-Muñoz et al (re:IBS)

    Genetic dissection of stool frequency implicates vitamin B1 metabolism and other actionable pathways in the modulation of gut motility Gut. 2026 Jan 20 PMID: 41558814 DOI: 10.1136/gutjnl-2025-337059 Cristian Díaz-Muñoz, et al. Open Access Abstract Background: Genetic...
  5. Andy

    Preprint Advancing Digital Precision Medicine for Chronic Fatigue Syndrome through Longitudinal Large-Scale Multi-Modal Biological Omics Modeling... 2025 Xiong

    Full title: Advancing Digital Precision Medicine for Chronic Fatigue Syndrome through Longitudinal Large-Scale Multi-Modal Biological Omics Modeling with Machine Learning and Artificial Intelligence We studied a generalized question: chronic diseases like ME/CFS and long COVID exhibit high...
    • Andy
    • Thread
    • amino acids bile acid biomapai butyrate gamma-delta t cells gut microbiome lipids machine learning mait cells metabolism sphingolipids tryptophan
    • Replies: 4
    • Forum: ME/CFS research
  6. SNT Gatchaman

    Interferon-Linked Lipid and Bile Acid Imbalance Uncovered in Ankylosing Spondylitis in a Sibling-Controlled Multi-Omics Study, 2025, Wang et al.

    Interferon-Linked Lipid and Bile Acid Imbalance Uncovered in Ankylosing Spondylitis in a Sibling-Controlled Multi-Omics Study Ankylosing spondylitis (AS) displays wide inter-patient variability that is not accounted for by HLA-B27 alone, suggesting that additional immune and metabolic...
    • SNT Gatchaman
    • Thread
    • ankylosing spondylitis bile acid fatty acid metabolism fatty acid oxidation il-17 il-23 innate immune system interferon lipids mitochondria neutrophils peroxisome s100 tnf
    • Replies: 5
    • Forum: Other health news and research
  7. SNT Gatchaman

    Review The Critical Role of the Bile Acid Receptor TGR5 in Energy Homeostasis: Insights into Physiology and Therapeutic Potential, 2025, Zangerolamo et al.

    The Critical Role of the Bile Acid Receptor TGR5 in Energy Homeostasis: Insights into Physiology and Therapeutic Potential Zangerolamo, Lucas; Carvalho, Marina; Barbosa, Helena C. L. Over the past decades, bile acids have been recognized as important signaling molecules with significant roles...
  8. SNT Gatchaman

    Osteoarthritis treatment via the GLP-1–mediated gut-joint axis targets intestinal FXR signaling, 2025, Yang et al.

    Osteoarthritis treatment via the GLP-1–mediated gut-joint axis targets intestinal FXR signaling Yuanheng Yang; Cong Hao; Tingying Jiao; Zidan Yang; Hui Li; Yuqing Zhang; Weiya Zhang; Michael Doherty; Chuying Sun; Tuo Yang; Jiatian Li; Jing Wu; Mengjiao Zhang; Yilun Wang; Dongxing Xie; Tingjian...
  9. pooriepoor91

    AI-driven multi-omics modeling of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome, 2025, Xiong et al.

    Now published - see post #20 Ruoyun Xiong, Elizabeth Aiken, Ryan Caldwell, Suzanne D. Vernon, Lina Kozhaya, Courtney Gunter, Lucinda Bateman, Derya Unutmaz & Julia Oh ******************************** https://www.biorxiv.org/content/10.1101/2024.06.24.600378v1 BioMapAI: Artificial Intelligence...
    • pooriepoor91
    • Thread
    • artificial intelligence bile acid biomapai gamma-delta t cells interferon interferon gamma lipids mait cells multi-omics unutmaz vernon
    • Replies: 44
    • Forum: ME/CFS research
  10. Andy

    Peroxisomal Regulation of Energy Homeostasis: Effect on Obesity and Related Metabolic Disorders, 2022, Kleiboeker and Lodhi

    Abstract Background Peroxisomes are single membrane-bound organelles named for their role in hydrogen peroxide production and catabolism. However, their cellular functions extend well beyond reactive oxygen species (ROS) metabolism and include fatty acid oxidation of unique substrates that...
  11. Andy

    Altered serum bile acid profile in fibromyalgia is associated with specific gut microbiome changes and symptom severity, 2022, Minerbi et al

    Abstract Alterations in the composition and function of the gut microbiome in women with fibromyalgia have recently been demonstrated, including changes in the relative abundance of certain bile acid metabolizing bacteria. Bile acids can affect multiple physiological processes, including...
  12. Andy

    Co-occurrence of gut microbiota dysbiosis & bile acid metabolism alteration is associated with psychological disorders in Crohn's disease, 2021, Feng

    Abstract This study aims to elucidate the relationships between gut microbiota, bile acid metabolism, and psychological comorbidity in Crohn's disease (CD). We profiled the fecal microbiota composition and quantified the bile acid pool of 39 CD patients and 14 healthy controls using 16S rRNA...
  13. Andy

    Multi-‘omics of gut microbiome-host interactions in short- and long-term myalgic encephalomyelitis/chronic fatigue syndrome patients, 2023, Xiong

    Study now printed, see https://www.s4me.info/threads/preprint-multi-omics-of-host-microbiome-interactions-in-short-and-long-term-myalgic-encephalomyelitis-chronic-fatigue-syndrome-me-cfs-2021-xiong.23022/#post-459931 for abstract and link Preprint: Multi-omics of host-microbiome interactions in...
    • Andy
    • Thread
    • 2021 bile acid butyrate dysbiosis gut microbiome jackson labs me/cfs microbiome paper sphingomyelin
    • Replies: 23
    • Forum: ME/CFS research
  14. Andy

    Microbiome-encoded bile acid metabolism modulates colonic transit times, 2021, Li et al

    In mice. Highlights Gut microbiome-generated bile acids regulate colonic transit via TGR5. Lithocholic acid had the largest colonic pro-motility effect. Bile acids exert sex-biased effects on gut transit times. Enteric nervous system transcriptional responses are regional and...
  15. M

    Metabolic and behavioral features of acute hyperpurinergia and the maternal immune activation mouse model of autism spectrum disorder (2021) Naviaux

    This is the latest work of Dr Naviaux and colleagues on cell-danger response, on mice. Metabolic and behavioral features of acute hyperpurinergia and the maternal immune activation mouse model of autism spectrum disorder Abstract Since 2012, studies in mice, rats, and humans have suggested...
    • Milo
    • Thread
    • autism bile acid cell danger response ceramide glutathione naviaux sphingolipids sphingomyelin
    • Replies: 0
    • Forum: Other health news and research
  16. Andy

    Prevalence of biliary acid malabsorption in patients with chronic diarrhoea of functional characteristics: a prospective study, Flores et al, 2021

    Open access, https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-021-01637-4
  17. Andy

    Bile Acid Signaling in Neurodegenerative and Neurological Disorders, 2020, Grant and DeMorrow

    Open access, https://www.mdpi.com/1422-0067/21/17/5982/htm
  18. Andy

    A metabolic pathway for bile acid dehydroxylation by the gut microbiome, 2020, Almo et al

    Paywall, https://www.nature.com/articles/s41586-020-2396-4 Sci hub, https://sci-hub.tw/10.1038/s41586-020-2396-4
  19. Andy

    Bile acid-activated receptors and the regulation of macrophages function in metabolic disorders, 2020, Fiorucci et al

    Paywall, https://www.sciencedirect.com/science/article/abs/pii/S1471489220300175 Sci hub, https://sci-hub.tw/10.1016/j.coph.2020.04.008
  20. Andy

    Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells, 2020, Campbell et al

    Paywall, https://www.nature.com/articles/s41586-020-2193-0 Sci hub, https://sci-hub.tw/10.1038/s41586-020-2193-0
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