Cerebrovascular reactivity and cerebral autoregulation are improved in the supine posture compared to upright in healthy men and women, 2020, Favre+

Discussion in 'Other health news and research' started by SNT Gatchaman, Feb 4, 2025.

  1. SNT Gatchaman

    SNT Gatchaman Senior Member (Voting Rights)

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    Cerebrovascular reactivity and cerebral autoregulation are improved in the supine posture compared to upright in healthy men and women
    Michelle E. Favre; Valerie Lim; Michael J. Falvo; Jorge M. Serrador

    Cerebrovascular reactivity and cerebral autoregulation are two major mechanisms that regulate cerebral blood flow. Both mechanisms are typically assessed in either supine or seated postures, but the effects of body position and sex differences remain unclear.

    This study examined the effects of body posture (supine vs. seated vs. standing) on cerebrovascular reactivity during hyper and hypocapnia and on cerebral autoregulation during spontaneous and slow-paced breathing in healthy men and women using transcranial Doppler ultrasonography of the middle cerebral artery.

    Results indicated significantly improved cerebrovascular reactivity in the supine compared with seated and standing postures (supine = 3.45±0.67, seated = 2.72±0.53, standing = 2.91±0.62%/mmHg, P<0.0167). Similarly, cerebral autoregulatory measures showed significant improvement in the supine posture during slow-paced breathing. Transfer function measures of gain significantly decreased and phase significantly increased in the supine posture compared with seated and standing postures (gain: supine = 1.98±0.56, seated = 2.37±0.53, standing = 2.36±0.71%/mmHg; phase: supine = 59.3±21.7, seated = 39.8±12.5, standing = 36.5±9.7°; all P<0.0167). In contrast, body posture had no effect on cerebral autoregulatory measures during spontaneous breathing.

    Men and women had similar cerebrovascular reactivity and similar cerebral autoregulation during both spontaneous and slow-paced breathing. These data highlight the importance of making comparisons within the same body position to ensure there is not a confounding effect of posture.

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  2. SNT Gatchaman

    SNT Gatchaman Senior Member (Voting Rights)

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  3. Utsikt

    Utsikt Senior Member (Voting Rights)

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    Do they speculate on why this is?
     
    alktipping and Peter Trewhitt like this.
  4. forestglip

    forestglip Senior Member (Voting Rights)

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    They give a few ideas, but give "however"s for all of them and ultimately say they aren't sure.
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    Another study on breathing's influence on cerebral blood flow:

    S4ME thread: Respiratory influence on cerebral blood flow and blood volume – A 4D flow MRI study, 2025, Söderström et al. (Journal of Cerebral Blood Flow & Metabolism)
     

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