Chronic hepatitis C virus infection irreversibly impacts human natural killer cell repertoire diversity, 2018, Bjorkstrom et al

Open access at https://www.nature.com/articles/s41467-018-04685-9

Article about the study

https://ki.se/en/news/immune-system-does-not-recover-despite-cured-hepatitis-c-infection

 

The Canadian Association for the Study of the Liver, a national group of health-care providers and researchers, published its guidelines on testing and treating hepatitis C. It was in the news recently and it's recommended that testing should be for Canadians in a certain age bracket (born between 1945 and 1975).

I was tested many years ago to rule that out.

 

@Andy

Thank you for posting this paper.

cc : @JaimeS @Hip

In the link @Andy provided we read that Chronic Hepatitis C Infection impacts NK Cell diversity. Moreover in another paper we read that ME/CFS patients were found having low NK Cell Activity.

I found an interesting paper that connects TYRO3 (A Vitamin K-related Gene) with NK cell functions :

Link can be found here

TYRO3 potential relevance has been found by Machine Learning Methods, here is a post from May 2017 :

http://algogenomics.blogspot.com/20...al&utm_source=twitter.com&utm_campaign=buffer

Professor @Jonathan Edwards Do you believe this may be relevant?

 

Interestingly my aunt had really bad Hep C in her youth....really bad ME now...

 

It is because Canadian blood banks (also affecting blood products) did not test for Hep C during that time range and people may have been exposed to Hep C may it be from birth, or other mean of getting it (blood transfusion, blood-blood exposure such as sharing needles).