Cimetidine: An immune modulator that actually seems to be working for me

@Woolie this may be of interest:

https://www.ncbi.nlm.nih.gov/m/pubmed/18325031/

Montelukast inhibits tumour necrosis factor-alpha-mediated interleukin-8 expression through inhibition of nuclear factor-kappaB p65-associated histone acetyltransferase activity.

So TNF, IL-8 and NF-kB.exactly the genes that were found to be upregulated in a recent transcriptome study:



https://journals.sagepub.com/doi/10.1177/2058738418820402

 

Thank you, @S-VV, that's of great interest to me.

Welcome to the forum!

Actually, this makes a whole lot more sense than the neutrophil stuff. It seems to be acting on the really big players in our disease(s).

 

So pleased for you @Woolie - long may it continue!

 

Thanks @Woolie, this is fascinating. Long may it continue. I'd also be interested in anybody else's experiences with Cimetidine or Ranitidine over the long-term as one of my half-siblings had a strange illness that seemed to make him immediately allergic to everything, that was resolved (after three years and a lot of diagnostic work) by the latter. Plus when my symptoms first came along the doctor thought they resembled some kind of allergic reaction. Hence, as I already take a PPI, I have considered temporarily switching it for Ranitidine to see if it has any impact whatsoever.

(I should stress I'm generally very wary of doing something like this - but am working on the basis that it's an OTC medicine that is likely not to have serious side effects)

 

I take Ranitidine for MCAS. Although it helps with the symptoms related to this, I don't feel it helps with ME symptoms. But still, that it helps somehow is great for me.

 

After a course of ranitidine i developped microscopic colitis.

It is a well known trigger for it.