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Cognitive-behaviour therapy for chronic fatigue syndrome: comparison of outcomes within and outside the confines of a [RCT], 2007, Quarmby et al

Discussion in 'Psychosomatic research - ME/CFS and Long Covid' started by MSEsperanza, Feb 28, 2022.

  1. MSEsperanza

    MSEsperanza Senior Member (Voting Rights)

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    Quarmby L, Rimes KA, Deale A, Wessely S, Chalder T. Cognitive-behaviour therapy for chronic fatigue syndrome: comparison of outcomes within and outside the confines of a randomised controlled trial. Behav Res Ther. 2007;45(6):1085-1094. doi:10.1016/j.brat.2006.08.019

    https://pubmed.ncbi.nlm.nih.gov/17074300/

    Paywalled


    Abstract


    Outcomes for cognitive-behaviour therapy (CBT) in randomised controlled trials (RCTs) have rarely been compared to those in routine clinical practice. Taking the case of CBT for chronic fatigue syndrome (CFS), we evaluated the results of a successful RCT against those of the same treatment given in the same setting as part of routine practice. Fatigue and social adjustment scores were compared for patients who received CBT for CFS as part of a RCT and patients who received CBT as part of everyday clinical practice.

    The results in the RCT were superior to those in routine clinical practice. Between pre-treatment and 6-month follow-up, the RCT showed a larger reduction in fatigue and greater improvement in social adjustment than those in routine treatment. The changes in fatigue scores were similar for both groups during treatment but were greater in the RCT between post-treatment and follow-up.

    Potential reasons for the superior results of the RCT include patient selection, therapist factors and the use of a manualised treatment protocol. Practitioners need to pay particular attention to relapse prevention and ensuring adequate follow-up in addition to encouraging patients to continue with cognitive-behavioural strategies once treatment has ended.
     
    Last edited: Mar 1, 2022
    DokaGirl, Peter Trewhitt and Trish like this.
  2. MSEsperanza

    MSEsperanza Senior Member (Voting Rights)

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    This is from 2007 but thought it was interesting with regard to how PACE investigators and defenders deal with their claims about effectiveness of treatments for CFS.

    Added a tag 'non-evidenced claims of effectiveness'.

    Any amendment of the tag's name or additional tags appreciated.

    Edit: Added a "Pre-PACE" to the tags.
     
    Last edited: Feb 28, 2022
    Sean, alktipping, DokaGirl and 3 others like this.
  3. DokaGirl

    DokaGirl Senior Member (Voting Rights)

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    So, you're not socially adjusted if you have a very debilitating physical disease....

    RCTs by definition are more controlled than clinical practice. Everything is supposedly more structured, including researcher and study subject engagement. Thus allowing researchers to perhaps more frequently remind study subjects they are feeling better.
     

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