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Connection between lactate, hypoxia, and inflammation

Discussion in 'Other health news and research' started by Guest 2176, Dec 10, 2019.

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  1. Guest 2176

    Guest 2176 Guest

    Guest 2176, Dec 10, 2019
    #1
    ScottTriGuy, sb4 and Milo like this.
  2. Guest 2176

    Guest 2176 Guest

    Hypoxia and glycolysis have long been appreciated to promote immune cell activation. In 2019, several studies highlighted a counterbalancing homeostatic function for the glycolytic metabolite lactate. Lactate directly suppresses signalling pathways and modifies histones to play an important role in regulating macrophage polarization, tumour immunity and antiviral responses.
     
    Guest 2176, Dec 10, 2019
    #2
    MeSci, Amw66, ScottTriGuy and 3 others like this.

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