inflammation

Cytokine‐Driven Hyperinflammation in Long COVID: Mechanisms, Biomarkers, Complement Dysregulation, and Emerging Immunotherapies—A Narrative Review Obeagu, Emmanuel Ifeanyi ABSTRACT Background and Aims Long COVID, also known as post-acute sequelae of SARS-CoV-2 infection (PASC), is a...

Circulating Drivers of Pathophysiology in Post-COVID-19 Sequelae Abstract Introduction: According to the WHO, post-COVID-19 sequelae impose an increased burden of illness and comorbidities among survivors. The present study evaluated systemic clinical complications associated with the...

Intestinal flagellin drives multisystem inflammation through TLR5-IL-15-ARA axis BACKGROUND Systemic inflammatory diseases including rheumatoid arthritis (RA), ankylosing spondylitis (AS), IBD and long covid share convergent multi-organ phenotypes. Long covid provides a tractable model for...

Uncovering the hidden biology of fibrinaloid microclot complexes in complex, inflammatory diseases Grixti, Justine; Pretorius, Etheresia; Kell, Douglas B. Abstract Abstract Blood can clot into anomalous, fibrinolysis-resistant forms that arise from prothrombotic seeding areas, including...

Pathogen effects on the brain: the case of SARS-CoV-2 spike protein and neuro COVID Theoharides, Theoharis C.; Papadopoulou, Paraskevi Abstract Many patients develop cognitive and neuropsychiatric issues after viral infections, but the mechanisms are not well understood. A case in point is...

Human haematopoietic stem cells remember inflammatory stress Inflammation activates blood cells, contributing to ageing and malignancy1,2,3. Haematopoietic stem cells (HSCs) survive a lifetime of infection to sustain life-long haematopoiesis1,2,3,4,5,6,7,8,9, but how human HSCs respond and...

(opens in new tab) Interleukin 6 as a Treatment Target for Depression Visual Abstract. Importance Interleukin 6 (IL-6), a keystone inflammatory cytokine, is a credible mechanistic candidate for causing depression. However, randomized clinical trials testing its treatment potential remain...

The effect of pre-existing sleep disturbance on T cell responses to SARS-CoV-2 variants, pro-inflammatory and pro-resolving mediators, and glucocorticoid sensitivity in Long COVID Sleep disturbance is highly common in Long COVID (LC), and is known to worsen infection outcomes and hinder full...

Link to the article: https://mecfsscience.org/immune-findings-in-me-cfs/

Ageing is accompanied by declining memory function, with extremely heterogeneous manifestation in the human population. Brain-extrinsic factors influencing cognitive decline, such as gastrointestinal signals, have emerged as attractive targets for peripheral interventions but the underlying...

Microbiota-derived extracellular vesicles link intestinal dysbiosis to neuroimmune activation in long COVID Post COVID-19 condition (Long COVID, LC) is frequently accompanied by persistent neurological symptoms, but the mechanisms linking intestinal dysbiosis to neuroinflammation remain...

Plasma proteomic profile reveals persistent immune activation in post-acute sequelae of SARS-CoV-2 infection Plasma proteomic profiling of 92 individuals with Post-Acute Sequelae of SARS-CoV-2 infection (PASC), assessed a mean of 34 months after acute infection, revealed a distinct...

Neuroinflammation: an unfortunate term to describe schizophrenia Abstract Schizophrenia, a chronic psychiatric disorder, has prompted extensive research into its immunological aspects. Studies in genetics, epidemiology, and treatment have revealed immune changes associated with schizophrenia...

Combination antiviral and anti-inflammatory therapy mitigates persistent neurological deficits in mice post SARS-CoV-2 infection Post-acute sequelae of COVID-19 (PASC) encompasses persistent neurological disease, including olfactory and cognitive dysfunction. The basis for this dysfunction is...

Highlights • IL-1β uniquely triggers self-imposed social withdrawal during inflammation • IL-1R1-positive DRN serotonergic neurons mediate social withdrawal • A peripheral-to-central IL-1β relay sustains prolonged social withdrawal Summary Sick animals exhibit behavioral changes that extend...

Persistent lung and vascular inflammation in mild to moderate COVID-19 survivors detected by ¹⁸F-FDG PET/CT: A quantitative imaging study with implications for cardiovascular risk PURPOSE Lingering inflammation after COVID-19 has been proposed as a contributor to long-term cardiovascular risk...

A Comparative Study of the Coagulation Systems and Inflammatory Profiles of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Patients with Long COVID Hayley Emma Arron Supervisor: Prof. Etheresia Pretorius Stellenbosch University [Line breaks added] Abstract Myalgic...

Muscle Abnormalities in Nonhospitalised Patients With Post–COVID-19 Condition BACKGROUND Post-COVID condition (PCC) affects ~10% of SARS-CoV-2–infected individuals and manifests as persistent symptoms such as fatigue, exercise intolerance and muscle weakness. This study aimed to assess the...

Abstract Inherited deficiency of zinc finger NFX1-type containing 1 (ZNFX1), a dsRNA virus sensor, is associated with severe familial immunodeficiency, multisystem inflammatory disease, increased susceptibility to viruses, and early mortality. However, limited treatments for patients with...

Sex differences in inflammation and markers of gut integrity in long COVID Endothelial damage represents an essential pathogenic mechanism of respiratory and multiorgan dysfunction as seen in the post-acute phase of COVID-19. Biological differences between male and female sex, inflammation...