Review Creatine and post-viral fatigue syndrome: an update 2025 Ostojic et al

[Andy]

ABSTRACT​

Post-viral fatigue syndrome, classified as a neurological condition by the WHO (ICD-11 code: 8E49), manifests as persistent fatigue, cognitive difficulties, and post-exertional malaise following viral infections. It shares commonalities with chronic fatigue syndrome and myalgic encephalomyelitis but is distinct due to its association with preceding viral events. Emerging research identifies bioenergetic disruptions, particularly mitochondrial dysfunction and impaired creatine metabolism, as key contributors. Recent studies suggest creatine supplementation may alleviate symptoms and improve energy metabolism. This narrative review summarizes recent advancements in utilizing creatine as a diagnostic and therapeutic target for post-viral fatigue syndrome and explores future directions for its application in managing this perplexing condition.

Open access

 

[Andy]

"PVFS often includes symptoms such as cognitive difficulties (commonly referred to as “brain fog”), intermittent and unrefreshing sleep, and post-exertional malaise, which involves a worsening of symptoms after physical or mental exertion [Citation1]. It shares considerable overlap with diagnoses such as chronic fatigue syndrome and myalgic encephalomyelitis, but it is distinct in its direct association with an antecedant viral infection. However, PVFS is often considered an umbrella term that encompasses these and other related conditions, including fibromyalgia, due to their commonalities in symptoms, prognosis, and management strategies [Citation2,Citation3]."