Indigophoton
Senior Member (Voting Rights)
This is a review article. I'm posting it for background reference, and because the description of FND signs in the paper doesn't look anything like ME (not to say that there isn't overlap, but this set of signs doesn't capture or describe ME. It sounds distinct and rather different).
https://jamanetwork.com/journals/jamaneurology/fullarticle/2682656?
Abstract
Importance Functional neurological disorders (FND) are common sources of disability in medicine. Patients have often been misdiagnosed, correctly diagnosed after lengthy delays, and/or subjected to poorly delivered diagnoses that prevent diagnostic understanding and lead to inappropriate treatments, iatrogenic harm, unnecessary and costly evaluations, and poor outcomes.
Observations Functional Neurological Symptom Disorder/Conversion Disorder was adopted by the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, replacing the term psychogenic with functionaland removing the criterion of psychological stress as a prerequisite for FND. A diagnosis can now be made in an inclusionary manner by identifying neurological signs that are specific to FNDs without reliance on presence or absence of psychological stressors or suggestive historical clues. The new model highlights a wider range of past sensitizing events, such as physical trauma, medical illness, or physiological/psychophysiological events. In this model, strong ideas and expectations about these events correlate with abnormal predictions of sensory data and body-focused attention. Neurobiological abnormalities include hypoactivation of the supplementary motor area and relative disconnection with areas that select or inhibit movements and are associated with a sense of agency. Promising evidence has accumulated for the benefit of specific physical rehabilitation and psychological interventions alone or in combination, but clinical trial evidence remains limited.
Conclusions and Relevance Functional neurological disorders are a neglected but potentially reversible source of disability. Further research is needed to determine the dose and duration of various interventions, the value of combination treatments and multidisciplinary therapy, and the therapeutic modality best suited for each patient.
Positive Signs in Categories of Functional Movement Disorders
Functional Poverty of Movement (Weakness and Slowness)
General Features
Leg Weakness
- Extreme slowness and fatigue
- Giveway weakness
- Inconsistency in performance
Arm Weakness
- Hoover sign
- Hip abductor signa
- Able to stand on toes or ankles despite weak plantarflexion or dorsiflexion on bed
Parkinsonism
- Drift without pronation
- Finger abduction signb
- Able to remove objects from bag or put on clothes inconsistent with upper limb examination
Functional Excess of Movement
- Lack of speed or amplitude decrement on repetitive tapping (sequence effect)
- Variable resistance during passive manipulation (Gegenhalten)
Tremor
Myoclonus
- Variability in frequency
- Entrainment or full suppressibilityc
- Tonic coactivation of antagonistic muscles at tremor onset
- Pause during contralateral ballistic movements
- Whack-a-mole signd
Dystonia
- Entrainment or full suppressibility
- Variability in duration and or distribution of jerks or of their latency (if stimulus sensitive)
- Predominance of axial or facial jerks
Tics
- Fixed dystonia at onset
- Variable resistance to passive manipulation
- Lack of sensory trick
- Lack of overflow
- Face: tonic pulling of the lips or jaw to 1 side; closed eyelids resist retraction by examiner
Functional Axial Manifestations
- Not fully stereotypical
- Interference with speech or voluntary actions
- Lack of premonitory urge
- Inability to voluntarily suppress tics
Gait
Posture
- Knee buckling
- Dragging gait with forefoot in contact with ground
- Excessive slowness or a gait similar to walking on ice
Balance
- Variability of positions over time
- Inconsistent, uneconomic postures
Speech
- No or controlled falls despite excessive swaying when walking
- Swaying and imbalance lessened with dual tasks
a Hip abductor sign is weakness of hip abduction in a paretic leg that resolves with contralateral hip abduction against resistance in the normal leg.
- Effortful speech
- Sudden onset of dysphonia, stuttering, or dysprosody
- Foreign accent
b Finger abduction sign is weakness of fingers abduction that resolves with contralateral finger abduction against resistance.
c Entrainment or ceasing of tremor to externally cued rhythmic movement or an inability to copy movement.
d Whack-a-mole sign is the emergence or worsening of an involuntary movement in a separate body part when the initially affected body part is suppressed by someone holding it down.
https://jamanetwork.com/journals/jamaneurology/fullarticle/2682656?