Cyclophosphamide drug questions?

Cornwall13 said:
Wonder if someone could help clarify things please.

Is the CycloME Part A trial being published any time soon?

Does the results from rituximab lower expectations for the results for cyclo?

Also, what is the theory behind cyclo working in ME?

Thanks
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It is due to be published early 2018.

I can't speak about the expectations, but clearly the trial investigators believe it has an effect as they extended the original follow up period and then they proceeded with part B.

I spoke with one of the investigators at iime and she indicated that it works, however I don't know if this means a whole lot, given they probably believed rituximab worked too.
 
BurnA said:
It is due to be published early 2018.

I can't speak about the expectations, but clearly the trial investigators believe it has an effect as they extended the original follow up period and then they proceeded with part B.

I spoke with one of the investigators at iime and she indicated that it works, however I don't know if this means a whole lot, given they probably believed rituximab worked too.
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Thanks for reply

I'm just concerned that Cyclophosphamide treatment rationale is the same as rituximab. Due to the negative results from rituximab, whether this means cyclophosphamide probability of working is lowered
 
Cornwall13 said:
I'm just concerned that Cyclophosphamide treatment rationale is the same as rituximab.
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It seems to have a completely different mechanism:

Medicinenet said:
Cyclophosphamide is a drug that is used primarily for treating several types of cancer. In order to work, cyclophosphamide first is converted by the liver into two chemicals, acrolein and phosphoramide. Acrolein and phosphoramide are the active compounds, and they slow the growth of cancer cells by interfering with the actions of deoxyribonucleic acid (DNA) within the cancerous cells. Unfortunately, normal cells also are affected, and this results in serious side effects. In addition to slowing the growth of cancerous cells, cyclophosphamide also suppresses the immune system and is referred to as immunosuppressive.
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https://www.medicinenet.com/cyclophosphamide/article.htm
 
So would we be looking for what is considered a side effect for cancer patients?

It is also something that suppresses B cells, which was my assumption about why they picked it. This possibly is bad news. Though there was something reassuring about cyclo looking more promising in with the :( news IIRC
 
Cornwall13 said:
I'm just concerned that Cyclophosphamide treatment rationale is the same as rituximab.
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I think the background is similar, in that cancer patients with ME seemed to recover.
However it does have a much broader effect than rtx, so if the problem is in the immune system, just because rtx failed, wouldn't necessarily suggest that cyclo will fail too.
 
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