1. Guest, the 'News in Brief' for the week beginning 3rd May 2021 is here.
    Dismiss Notice
  2. Welcome! To read the Core Purpose and Values of our forum, click here.
    Dismiss Notice

Diagnosis of mast cell activation syndrome: a global “consensus-2”, 2020, Afrin et al

Discussion in 'Immune: Autoimmune and Mast Cell Disorders' started by Dolphin, Apr 28, 2020.

  1. Dolphin

    Dolphin Senior Member (Voting Rights)

    Messages:
    2,942
    Likes Received:
    16,378
    Free full text: https://www.degruyter.com/view/jour...dx-2020-0005/article-10.1515-dx-2020-0005.xml
     
  2. Michiel Tack

    Michiel Tack Senior Member (Voting Rights)

    Messages:
    2,309
    Likes Received:
    22,393
    Location:
    Belgium
    This sentence seems to sum up the paper and the whole MCAS situation:
     
    zzz, leokitten, MSEsperanza and 16 others like this.
  3. Jonathan Edwards

    Jonathan Edwards Senior Member (Voting Rights)

    Messages:
    8,928
    Likes Received:
    95,020
    Yes, but what does it mean?
    Superficially the situation might be similar to ME, where arguing about criteria gets in the way of helping a group of people with a clinical syndrome we know exists. But we do not know that a syndrome due to one or more (unspecified) problems with mast cell activation exists. If the prevalence is estimated to be somewhere between less than 1% - people with disorders of tryptase levels maybe - to 17% then we can be pretty sure nobody actually nows if this exists or not. And why is one of the authors someone who is an advocate for Ehlers-Danlos syndrome, which has nothing to do with MCAS?
     
    Wyva, shak8, Mij and 4 others like this.
  4. Theresa

    Theresa Established Member

    Messages:
    22
    Likes Received:
    89
    According to Wikipedia Afrin suggests that MCAS could cause spontaneous human combustion, presumably there is no such thing and that cannot be a valid theory? I recall reading a very long article by him years ago on MCAS dymptoms and thinking it sounded like me until I got to the end and he brought in spontaneous human combustion and then I discounted the whole thing.
     
    Last edited: May 1, 2020
    Tia likes this.
  5. MSEsperanza

    MSEsperanza Senior Member (Voting Rights)

    Messages:
    1,551
    Likes Received:
    11,186
    Location:
    betwixt and between
    Don't know if this paper warrants an own thread --the first author is also a co-author of the 'golbal consensus':

    Code:
    https://twitter.com/awgaffney/status/1358474398706106370/CODE]
    

    Code:
    https://twitter.com/awgaffney/status/1358474406859862020
    Edit: clarity and fixed links.

    Edit 2: No idea how the tweeter's stance on other evidence in LC is, I just thought the info about Afrin's and Weinstock's and also Theoharides' COI, if true, is interesting.
     
    Last edited: Feb 8, 2021
    Wyva likes this.

Share This Page