Discussion in 'Immune: Autoimmune and Mast Cell Disorders' started by Dolphin, Apr 28, 2020.
Free full text: https://www.degruyter.com/view/jour...dx-2020-0005/article-10.1515-dx-2020-0005.xml
This sentence seems to sum up the paper and the whole MCAS situation:
Yes, but what does it mean?
Superficially the situation might be similar to ME, where arguing about criteria gets in the way of helping a group of people with a clinical syndrome we know exists. But we do not know that a syndrome due to one or more (unspecified) problems with mast cell activation exists. If the prevalence is estimated to be somewhere between less than 1% - people with disorders of tryptase levels maybe - to 17% then we can be pretty sure nobody actually nows if this exists or not. And why is one of the authors someone who is an advocate for Ehlers-Danlos syndrome, which has nothing to do with MCAS?
According to Wikipedia Afrin suggests that MCAS could cause spontaneous human combustion, presumably there is no such thing and that cannot be a valid theory? I recall reading a very long article by him years ago on MCAS dymptoms and thinking it sounded like me until I got to the end and he brought in spontaneous human combustion and then I discounted the whole thing.
Don't know if this paper warrants an own thread --the first author is also a co-author of the 'golbal consensus':
Edit: clarity and fixed links.
Edit 2: No idea how the tweeter's stance on other evidence in LC is, I just thought the info about Afrin's and Weinstock's and also Theoharides' COI, if true, is interesting.
Separate names with a comma.