Dorsal root ganglia: fibromyalgia pain factory?, 2021, Martinez-Lavin

Open access, https://link.springer.com/article/10.1007/s10067-020-05528-z

Edited to break up paragraphs for ease of reading.

 

Inflammation of the dorsal root ganglia have been found in autopsies of people with ME.

"Fibromyalgia is clearly a stress-related disorder. Psychological distress, physical trauma, and/or autoimmune illnesses are frequent fibromyalgia drivers. Dorsal root ganglia (DRG) have unique anatomical and physiological features making them able to convert varied afferent stressful impulses, including psychological distress, into neuropathic pain [3]."

The author's only reference for this is his unpublished work below:

3 Martínez-Lavín M (2020) Fibromyalgia in women: somatisation or stress-evoked, sex-dimorphic neuropathic pain? Clinical and experimental rheumatology. Advance online publication

 

By some sort of magic?

 

I have never heard that ME has "exercise-induced DRG pro-nociceptive molecules gene overexpression"

Diagnosing FM and ME is very lax. One doctor said that the criteria for FM was now so loose it was almost meaningless and it in things like FND FM means widespread pain and CFS means fatigue.

When things are found in patients with FM and ME together I wonder how much effort they have made to distinguish the severe myalgia of fibromyalgia with the severe myalgia of ME.

Maybe work like this will eventually be a proper test for FM and lead to a treatment but it seems like a way to bring biology to "stress related"

I am more interested in treatments for dorsal ganglia problems because it has been found at autopsy in the few autopsies that have been done on people with ME.