Dysregulation of FOXO transcription factors in Epstein-Barr virus-associated gastric carcinoma, 2019, Wen Liu et al.

wastwater · Dec 25, 2019

https://www.sciencedirect.com/science/article/abs/pii/S0168170219304873

Trish · Dec 25, 2019

Highlights

Epstein-Barr virus regulates the expression pattern of FOXO1, FOXO3 and FOXO4.

PI3K/AKT was activated in EBVaGC.

LMP1 and LMP2A increased the expression of FOXO1and FOXO3 in EBVaGC.
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Abstract
Epstein-Barr virus (EBV) infection is associated with the development of gastric cancer (GC). Forkhead box class O (FOXO) transcription factors play important roles in tumor suppression.

This study aims to investigate the interplay between EBV and FOXOs in EBV-associated GC (EBVaGC).

The results showed that EBV infection of GC cells led to the downregulation of FOXO1 by the inhibition of its mRNA and protein expression. FOXO3 protein is repressed by EBV infection. FOXO4 mRNA is upregulated in EBV-positive cell lines, while its protein expression is downregulated. FOXO1, FOXO3 and FOXO4 proteins are upregulated following PI3K inhibition in GT39 cells, confirming that they are partially suppressed by the PI3K/AKT pathway.

However, the upregulation of FOXO1 and FOXO3 by single transfection with LMP1 or LMP2A implies that the dysregulation of FOXOs in EBVaGC is affected by various EBV latent genes and that PI3K/AKT signaling is not the only mechanism of FOXO regulation.
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wastwater · Apr 9, 2020

Could this be at the heart of mecfs also
Doesn’t FOXO have something to do with the dauer state
If you genetically have lowered expression of FOXO maybe infection with EBV could Induce the dauer state

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Dysregulation of FOXO transcription factors in Epstein-Barr virus-associated gastric carcinoma, 2019, Wen Liu et al.

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Dysregulation of FOXO transcription factors in Epstein-Barr virus-associated gastric carcinoma, 2019, Wen Liu et al.

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