Eukaryotes in the gut microbiota in myalgic encephalomyelitis/chronic fatigue syndrome, 2018, Hanson et al

Adrian · Jan 23, 2018

A new paper from Maureen Hanson's group

https://peerj.com/articles/4282/

Eukaryotes in the gut microbiota in myalgic encephalomyelitis/chronic fatigue syndrome
Research article
Microbiology
Molecular Biology
Neurology
Alexandra H. Mandarano 1, Ludovic Giloteaux 1, Betsy A. Keller 2, Susan M. Levine 1, Maureen R. Hanson 1
January 22, 2018
Author and article information

Abstract

Patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) often suffer from gastrointestinal symptoms and many are diagnosed with irritable bowel syndrome (IBS). Previous studies, including from our laboratory, have demonstrated that the ME/CFS gut bacterial composition is altered and less diverse when compared to healthy individuals. Patients have increased biomarkers of inflammation and leaky gut syndrome. To further investigate dysbiosis in the ME/CFS gut microbiome, we sought to characterize the eukaryotes present in the gut of 49 individuals with ME/CFS and 39 healthy controls. Using 18S rRNA sequencing, we have identified eukaryotes in stool samples of 17 healthy individuals and 17 ME/CFS patients. Our analysis demonstrates a small, nonsignificant decrease in eukaryotic diversity in ME/CFS patients compared to healthy individuals. In addition, ME/CFS patients show a nonsignificant increase in the ratio of fungal phyla Basidiomycota to Ascomycota, which is consistent with ongoing inflammation in ME/CFS. We did not identify specific eukaryotic taxa that are associated with ME/CFS disease status.
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Adrian · Jan 23, 2018

Basically looks like a null result? They talk of small non-significant differences. But still interesting to see what they have looked at,

MErmaid · Jan 23, 2018

I appreciate her honesty and mention about the “high diversity between individuals”. We need more women research scientists studying ME.

https://twitter.com/user/status/955858475648565248

Manganus · Jan 24, 2018

Adrian said: ↑

Basically looks like a null result? They talk of small non-significant differences. But still interesting to see what they have looked at.
Click to expand...

To state the obvious:
Also a null-result is a result.

It's of no help in the quest for a biomarker.
But in the long run, maybe of help for the general understanding.
And lots of subclinical and "insignificant" findings seem to be a typical sign of ME.

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Eukaryotes in the gut microbiota in myalgic encephalomyelitis/chronic fatigue syndrome, 2018, Hanson et al

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