Evaluation of four clinical laboratory parameters for the diagnosis of myalgic encephalomyelitis (2018) De Meirleir et al

Discussion in 'ME/CFS research' started by hixxy, Nov 23, 2018.

  1. hixxy

    hixxy Senior Member (Voting Rights)

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    https://www.ncbi.nlm.nih.gov/pubmed/30463572
    https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-018-1696-z
     
    Inara, Daisymay, unicorn7 and 15 others like this.
  2. adambeyoncelowe

    adambeyoncelowe Senior Member (Voting Rights)

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    Anybody had time to look at this yet?
     
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  3. unicorn7

    unicorn7 Senior Member (Voting Rights)

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    I hope they will test more people and people with other diseases. I think a biomarker eventually will be different tests taken together to form a diagnosis, so this seems like a good start. We will just have to see if these parameters are really specific for ME.

    I had all these levels tested and in my case it's correct.
     
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  4. Helen

    Helen Senior Member (Voting Rights)

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    My test results (sCD14, PGE and Interleukin 8) were abnormal too.
     
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  5. alex3619

    alex3619 Senior Member (Voting Rights)

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    I have been expecting a finding of elevated PGE2 for two and a half decades. Why does it take so long? (rhetorical question)

    It seemed to me, based on early work by Dr Andriya Martinovic, plus work by Martin L Pall and others, that this was a fully expected consequence. I was trying various treatments based on this idea through most of the 90s.

    By itself PGE2 shows potential pathophysiology, its not diagnostic. I don't want to say anything about the other three substances yet. We will have to see how further research progresses before we know if this is diagnostically useful.
     
    Inara, Sunshine3 and adambeyoncelowe like this.

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