Genetics: SOX6

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I didn’t see a thread about SOX6, apologies if I missed it

SOX6 seems interesting as it is not only a peak in LocusZoom itself but also a Transcription Factor Binding Site mentioned in Genehancer data for promoters and enhancers for many (well most) other genes in the DecodeME candidate gene list (including other transcription factors).

 

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Question for the more knowledgeable. If a transcription factor itself and multiple genes with that transcription factor in transcription factor binding sites for their promoters and enhancers are all found (as they seem to have been here) would that cascade and magnify any effect?

I don’t know enough of the biology or if this is rare or common (it just stood out compared to other transcription factors in the list) but it seems like the sort of thing were a few small changes could quickly have an outsized impact.