Haunting innate immune memories of COVID-19, 2023, Birgit Sawitzki

Haunting innate immune memories of COVID-19

In addition to acute hyperinflammatory responses, SARS-CoV-2 infections can have long-term effects on our immune system leading to, for example, post-acute sequelae of COVID-19 (PASC). In this issue of Cell, Cheong et al. show that severe infections via IL-6 induce persistent epigenetic signatures in hemopoietic stem cells and their myeloid progenitors associated with increased inflammatory potential.

https://www.cell.com/cell/fulltext/S0092-8674(23)00848-6

 

See thread Epigenetic memory of coronavirus infection in innate immune cells and their progenitors, 2023, Cheong et al.