long covid

Abstract The COVID-19 pandemic, caused by SARS-CoV-2, has resulted in widespread morbidity and mortality, with a significant portion of the affected population experiencing long-term health complications. This review explores the mechanisms of mitochondrial dysfunction in both the acute and...

Cytokine profiles associated with persisting symptoms of post-acute sequelae of COVID-19 Ji-Soo Kwon, Euijin Chang, Hyeon Mu Jang, Ji Yeun Kim, Woori Kim, Ju Yeon Son, Junho Cha, Choi Young Jang, Seongman Bae, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim...

Key points: SPEAR Study Group initiated following multiple, independent reports of substantial clinical benefit associated with PEMGARDA® (pemivibart) therapy among people with Long COVID SPEAR Study Group collaborators Drs. Michael Peluso, Amy Proal, and David Putrino are key thought leaders...

REGAIN: A Randomized Controlled Clinical Trial of Oxaloacetate for Improving the Symptoms of Long COVID Suzanne D Vernon, Candace Rond, Jennifer Bell, Brindisi Butler, Sara Isolampi, Annaleah Otteson, Pearl Phalwane, Samantha Mower, Shad Roundy, David Kaufman, Alan Brian Cash, Lucinda Bateman...

Abstract Background: Acute COVID-19 alters the airway microbiota. Whether these changes persist post-COVID-19 and contribute to Long COVID (LC) is unknown. We aimed to describe the microbiota based on LC severity and subtype; and identify links with inflammation to find potential therapeutic...

Hybrid Pulmonary Rehabilitation Improves Cardiorespiratory Exercise Fitness in Formerly Hospitalised Long COVID Patients Nikolaos Chynkiamis, Angelos Vontetsianos, Christina Anagnostopoulou, Christiana Lekka, Maria Ioanna Gounaridi, Evangelos Oikonomou, Manolis Vavuranakis, Nikoleta Rovina...

Full title: Immune Signatures in Post-Acute Sequelae of COVID-19 (PASC) and Myalgia/Chronic Fatigue Syndrome (ME/CFS): Insights from the Fecal Microbiome and Serum Cytokine Profiles Abstract While there are many postulates for the etiology of post-viral chronic fatigue and other...

Awe reduces depressive symptoms and improves well-being in a randomized-controlled clinical trial https://www.nature.com/articles/s41598-025-96555-w Emerging evidence suggests that experiences of awe benefit health and well-being. The present investigation examined the efficacy of an awe...

Integrative Bioinformatics Analysis Identifies Peripheral Blood Hub Genes and Establishes a Five-Gene Diagnostic Model for Long COVID Yang Liu, Yuwei Shen, Peilian Cao, Yuqiang Qian, Yutong Chen, Daxing Jiang, Jianan Li [Line breaks added] Background Long COVID (LC) is a multisystem condition...

Effect of normobaric and hyperbaric hyperoxia treatment on symptoms and cognitive capacities in Long COVID patients: a randomised placebo-controlled, prospective, double-blind trial Leen D’hoore, Peter Germonpré, Bert Rinia, Leonard Caeyers, Nancy Stevens, Costantino Balestra [Line breaks...

https://www.preprints.org/manuscript/202506.2016/v1 Abstract Fatigue is the most common symptom of Long-COVID (LC), characterized by persistent or new symptoms occurring at least three months after the initial SARS-CoV-2 infection, with no other identifiable cause. This study aims to assess the...

I wasn't sure where to put the news about this group's July 9 webinar. So I created a new thread for the Patient-Led Research Fund organization. Please move this post if it belongs elsewhere. Website for Patient-Led Research Collaborative Linktree for Patient-Led Research Collaborative...

Dysregulated monocyte compartment in PACS patients Romy Kronstein-Wiedemann, Madeleine Teichert, Elisa Michel, Janina Berg, George Robinson, Kristin Tausche, Martin Kolditz, Johannes Bergleiter, Jessica Thiel, Dirk Koschel, Stephan R. Künzel, Kristina Hlig, Torsten Tonn, Manuela Rossol...

[68Ga]FAPI PET/CT reveals increased pulmonary fibroblast activation protein expression in long COVID patients after ICU discharge B. van Leer, M. Londema, Ö. Kasalak, J. H. van Snick, M. L. Duiverman, J. C. Kuijvenhoven, M. D. de Kruif, D. E. Oprea-Lager, K. Pabst, M. E. Hellemons, H. H...

RECLAIM: Recovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine Drug: Ibudilast 10mg pills, 2 pills twice per day Other Names: Drug: Pentoxifylline 400mg pill 3 times per day Other: Placebo Placebo matching ibudilast, 2 pills twice per day OR placebo matching...

P109 Circulating autoantibodies targeting G-protein-coupled neurotransmitter receptors: reliable biomarkers for long COVID diagnosis? M Camici, M Franco, L Talamanca, E Cimini, E Tartaglia, S Notari, M Petino, L Scarnecchia, A Vergori, R Baldelli, P Zuppi, A Antinori [Line breaks added]...

8: How Stigma Emerges and Mutates: The Case of Long COVID Stigma Hannah Farrimond, Mike Michael [Line breaks added] Introduction How do new stigmas emerge? How do they relate to existing stigma? Why are we seeing an emergent devaluation and discrimination of people who have long COVID, given...

Abstract Mitochondrial disease incorporates a group of rare conditions with no approved treatment to date, except for Leber hereditary optic neuropathy. Therapeutic options to alleviate the symptoms of mitochondrial disease are urgently needed. Sonlicromanol is a promising candidate, as it...

Effectiveness of Treating Post-COVID-19 Conditions (Long COVID) With the SARS-CoV-2 Specific Monoclonal Antibody, Sipavibart Brief Summary This placebo-controlled, randomized, blinded, two-arm phase II study will test the safety and potential efficacy of the targeted mAb, Sipavibart (formerly...

Long-term neurological and cognitive impact of COVID-19: a systematic review and meta-analysis in over 4 million patients Toka Elboraay, Mahmoud A. Ebada, Maged Elsayed, Heba Ahmed Aboeldahab, Hazem Mohamed Salamah, Omar Rageh, Mohamed Elmallahy, Hadeer Elsaeed AboElfarh, Lena Said Mansour...