Hi @TrixieStix, Plaquenil is a great tool in rheumatology in decreasing inflammation. It does not work right away, so you need to wait a good 6months to judge whether it is helping you. I took it for 10 years following an episode of small joint pain (fingers and toes) I was not formally diagnosed with any rheumatologic disease, but the fingers and toes pain was debilitating. With the addition of Plaquenil I was able to taper down the other anti-inflammatories I was on. Stopping Plaquenil made the joint pain to come back. With Plaquenil you need to have visual field exams on a regular basis as it can be toxic on the eyes. Best wishes.