Open Immunoadsorption in Autoimmune Long COVID (TURNLongCOVID)

[Dude]

ClinicalTrials.gov

clinicaltrials.gov

Brief Summary

Some people continue to have serious symptoms long after COVID-19, such as extreme fatigue and feeling worse after activity. In some patients, this may happen because the immune system is attacking the body by mistake.

This study will test a treatment called immunoadsorption, which filters the blood to remove harmful antibodies. People with long COVID who have these antibodies will be randomly assigned to receive either the real treatment or a placebo. The main goal is to see whether fatigue improves after one month, and whether other symptoms and daily functioning improve over six months.

This research will help us find out if this treatment can benefit the group of long COVID patients with immune-related disease.

 

[V.R.T.]

ClinicalTrials.gov

clinicaltrials.gov

Unless they've had advance sight of the Charite immunoadsorption blinded study results and they are positive (which is entirely possible) this seems premature to me.

At least they are using placebo from the start. But surely there must be a more effective and less arduous to administer drug that could test their passive transfer IgG theory?

 

[Jonathan Edwards]

Is the passive transfer to mice study published?

 

[EndME]

I think the a very unconvincing thing is that this team is supposed to have an antibody assay that is accurate in indentifiying Long-Covid developed with a commercial partner and this is what has been said in the media and elsewhere by den Dunnen et al for several years (see also here), but their publications on this topic have amounted to one mouse study that comes with all sorts of metholodgical problems.

It would be really nice to see the results of "We subsequently developed and validated a disease-specific Luminex multiplex immunoassay to detect this autoimmune phenotype.", rather than just the talks of it existing. None of the presentations at the conferences I've seen suggested it exists.

 

[Jonathan Edwards]

Is the passive transfer to mice study published?

Now I remember. I wasn't very complimentary about it, I see.