Improvement of ME/CFS during an infection

Intriguing..

MIT News, 2024: "Understanding why autism symptoms sometimes improve amid fever"

“To the best of my knowledge, the ‘fever effect’ is perhaps the only natural phenomenon in which developmentally determined autism symptoms improve significantly, albeit temporarily,” Huh says. “Our goal is to learn how and why this happens at the levels of cells and molecules, to identify immunological drivers, and produce persistent effects that benefit a broad group of individuals with autism.”
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Building on these studies, a 2020 paper clarified the fever effect in the setting of autism. This research showed that mice that developed autism symptoms as a result of maternal infection while in utero would exhibit improvements in their sociability when they had infections — a finding that mirrored observations in people. The scientists discovered that this effect depended on over-expression of IL-17a, which in this context appeared to calm affected brain circuits. When the scientists administered IL-17a directly to the brains of mice with autism-like symptoms whose mothers had not been infected during pregnancy, the treatment still produced improvements in symptoms.
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Nightsong

Thread 'Transient clinical improvement and immune modulation following recombinant Zoster vaccination in a patient with ME/CFS, 2026, Bigleri et al'

Abstract:

Introduction​

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating multisystem disorder associated with immune dysregulation yet lacks definitive biomarkers or effective therapies. Acute immune perturbations may transiently modulate disease manifestations.

Methods​

We report the case of a female patient in her 60s with severe, long-standing ME/CFS who experienced changes in symptom following administration of recombinant zoster vaccine (RZV; Shingrix). Peripheral blood mononuclear cells were analyzed pre- and post-vaccination using flow...
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For those of you with notable back pain/fibromyalgia as part of your ME/CFS symptoms. Have you noticed that it improved when you received a vaccination or had an infection? This is the third time this has happened to me (twice with an infection and once with a vaccination). I have very bad pain in the morning and at other times. And three times it just wasn't there when I woke up. Each time with infection/vaccine. Only three; so still quite likely to be by chance, but I thought I remembered someone else mentioning something like this; now cannot find that thread...
 
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LizWorthey said:
Merged thread

For those of you with notable back pain/fibromyalgia as part of your ME/CFS symptoms. Have you noticed that it improved when you received a vaccination or had an infection? This is the third time this has happened to me (twice with an infection and once with a vaccination). I have very bad pain in the morning and at other times. And three times it just wasn't there when I woke up. Each time with infection/vaccine. Only three; so still quite likely to be by chance, but I thought I remembered someone else mentioning something like this; now cannot find that thread...
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Ahh thank you - and I even commented on it before. My brain, I swear....
 
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