Thanks, agree that oxidative stress and low oxygen are 2 different things, however I go by conclusions made by researchers (quoted in my previous response) Ref pro inf cytokines, you will find several studies showing increased levels of IL6 , TNF-A, IL1 B. So I would not agree that "there is no rise in inflammatory cytokines". You could find plenty of researchers who would say otherwise. However, robustness, consistency and definitive counts are lacking, and in my view this is largely due to heterogeneous subgroups, broad spectrum spread of this condition and other factors. We all would love a "single piece of well established evidence", but I view this as very unlikely, given that this is not a one size fits all condition. Even the same person typically goes through remissions and relapses, during ebb and flow of this condition. So looking for one definitive "well established" biomarker may be difficult. It's just too fluid.