Keystone symposium Long COVID and Other Post-Acute Infection Syndromes August 10-13 2025

The organisers are being strict about not posting slides, graphs, tables etc so we'll have to wait for the actual publications for data and ascertainment details. But they were emphasising fatigue, postural symptoms, myalgia, poor sleep and brain fog, so that sounds broadly in the ball park.

The interpretation at the end relates to the Reactome pathways they found using the proteomics data. I think we've previously commented on limitations with pathway analysis with genomics, transcriptomics and proteomics.
 
The trouble is that subclinical comorbigdities are bound to impact case recruitment. A bit like the Beentjes study I think you are almost bound to pick up noise from that.

These people are at my hospital. I have had a clinical meeting with them. I won't say more but I didn't get a feel for a clear focus.
 
A question I might as well put here. If we think people with post infective fatigue have a prolonged immune signature that could be picked up on blood samples it would be worth checking known post-infective syndromes. The obvious ones are Reiters and post streptococcus psoriasis. In these we know there is a persistently abnormal immune response that can produce major tissue pathology. But at least when I was working I heard nothing about any consistent findings in blood that shed light on what was going on.

So maybe we should not expect to find anything.
 
During Danny Altman's plenary, discussing the major impact on children they're seeing as part of their larger study —

"And it's very tough to see and it was hard for us because we found it very hard to get the funding agreed from our funder. Because at the last moment they said the advice we've had from our referees at the Dept of Health is not to fund the paediatric part of the study because their advice is that Long Covid in children is purely psychological. And it's just that it takes them a few months to recover from their acute Covid and otherwise they're completely well. So we're very worried you'll have nobody to study. So this is my response to that... it's hard to watch."

On screen is EQ5D-Y prospective data of children 9-17, similar at baseline to fully recovered children. The chart shows significant or some problems having developed 2 years later in: mobility, looking after myself, doing usual activities, pain or discomfort, being worried sad or unhappy. In particular the scores for "no problems" in domains: doing usual activities, pain or discomfort have fallen off a cliff. Other domains are nearly as bad.
 
You must log in or register to reply here.
Back
Top Bottom