Local immune response to food antigens drives meal-induced abdominal pain, 2021, Aguilera-Lizarraga et al

[InfiniteRubix]

Local immune response to food antigens drives meal-induced abdominal pain

https://www.nature.com/articles/s41586-020-03118-2

Article Published: 13 January 2021 Local immune response to food antigens drives meal-induced abdominal pain

Javier Aguilera-Lizarraga, Morgane V. Florens, […]Guy E. Boeckxstaens Nature (2021)Cite this article 41 Altmetric Metricsdetails

Abstract

Up to 20% of people worldwide develop gastrointestinal symptoms following a meal1, leading to decreased quality of life, substantial morbidity and high medical costs. Although the interest of both the scientific and lay communities in this issue has increased markedly in recent years, with the worldwide introduction of gluten-free and other diets, the underlying mechanisms of food-induced abdominal complaints remain largely unknown. Here we show that a bacterial infection and bacterial toxins can trigger an immune response that leads to the production of dietary-antigen-specific IgE antibodies in mice, which are limited to the intestine. Following subsequent oral ingestion of the respective dietary antigen, an IgE- and mast-cell-dependent mechanism induced increased visceral pain. This aberrant pain signalling resulted from histamine receptor H1-mediated sensitization of visceral afferents. Moreover, injection of food antigens (gluten, wheat, soy and milk) into the rectosigmoid mucosa of patients with irritable bowel syndrome induced local oedema and mast cell activation. Our results identify and characterize a peripheral mechanism that underlies food-induced abdominal pain, thereby creating new possibilities for the treatment of irritable bowel syndrome and related abdominal pain disorders.

 

[mat]

Funny enough, IBS, as to how such related things are often generalized, is also attributed to the psyche by some medical folks. Because it's impossible to consider that the significantly increased amounts of gluten, sugars and hormones could lead to it. Just like it is a coincidence that children's puberty shifts to earlier and earlier ages.

 

[ME/CFS Skeptic]

This Belgian article was featured in the press:

Biologisch mechanisme dat prikkelbaredarmsyndroom veroorzaakt ontrafeld | EOS Wetenschap
Onderzoekers KU Leuven ontdekken mechanisme dat prikkelbaredarmsyndroom veroorzaakt | VRT NWS: nieuws

If I understand correctly, the authors think that IBS is related to mast cell activation and they propose antihistamines should be further studied as a treatment.

 

[InitialConditions]

"Up to 20% of people worldwide develop gastrointestinal symptoms following a meal" Not exactly sure what this means. Does it mean 20% have regular issues, or that 80% of people have never had gastrointestinal symptoms following a meal (which surely cannot be the case)?

 

[Mij]

Because it's impossible to consider that the significantly increased amounts of gluten, sugars and hormones could lead to it. Just like it is a coincidence that children's puberty shifts to earlier and earlier ages.

A major contributing factor is child obesity that has increased in the last 2+ decades. Perhaps because of higher levels of the fat-regulating hormone leptin?

There's also a study (studies) that indicate associations to chemicals (phthalates etc) in products. I can't believe the amount of products people (mostly young women) apply to their skin that disrupt hormones.

 

[Hoopoe]

I can't believe the amount of products people (mostly young women) apply to their skin that disrupt hormones.

Mystery illnesses in young women could be in part due to cosmetic product toxicity.

It's funny how mouse models of human disease are considered highly unreliable, but animal models of toxicity are somehow considered safe and reliable.

 

[leokitten]

Scientists May Have Finally Found a Key Mechanism Behind Irritable Bowel Syndrome

 

[Hutan]

Cort has written about this study:
https://www.healthrising.org/blog/2...on-ibs-fibromyaglia-chronic-fatigue-syndrome/
suggesting

It offers an explanation for several of the mysteries that have permeated the IBS, ME/CFS, FM, and other fields. It shows how an infection can lay the groundwork for a chronic disease, it demonstrates why standard measures of inflammation have never revealed much, it shows how easily the causes of diseases like these can be hidden, and it shows how the nerves come into play. Plus, it validates something ME/CFS experts consider to be a hot topic (mast cell activation syndrome (MCAS) but which the medical research field has yet to embrace.

Not bad!

I'm interested to see if that is really the case.

 

[Andy]

I'm interested to see if that is really the case.

In my experience, anything Cort claims is always best taken with a big pinch of salt.