Long COVID involves activation of proinflammatory and immune exhaustion pathways, 2025, Aid et al.

PageofME said:

Meta-analysis of natural killer cell cytotoxicity in myalgic encephalomyelitis/chronic fatigue syndrome - PMC

Reduced natural killer (NK) cell cytotoxicity is the most consistent immune finding in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Meta-analysis of the published literature determined the effect size of the decrement in ME/CFS. ...
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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I find that the easiest way to check if a study has been posted here is to search for the name of the first author and tick off the titles only box.
 
To be fair, the Baraniuk, Eaton-Finch and M-Gradisnik paper is a bit puzzling.
Sonya M-G originally worked with Nancy Klimas on NK cells. Klimas never seemed to be able to reproduce the findings in a way that could be used in a clinical setting. James Baraniuk muttered an aside to me in 2015 that Nancy couldn't even replicate the basic data.

Fast forward ten years and James is teaming up with Sonya and co to write this despite the fact that nobody else much has been able to substantiate it as far as I know. A bit weird.

But the real bottom line for me is that nobody really knows what these NK tests mean in immunocompetence terms and they are notoriously difficult to get consistent. If there really was immunocompromise we should see opportunistic infection and we don't. I am pretty sure that the whole idea dates back to the AIDS days when a few people thought ME/CFS might be similar to AIDS. But that never panned out. There was no retrovirus. There were no consistent cell changes. Nobody with ME/CFS got pneumocystis pneumonia or Kaposi's sarcoma. It just wasn't there.
 
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