Long-term exposure to bisphenol A or S promotes glucose intolerance & changes hepatic mitochondrial metabolism in male Wistar rats, 2019,Azevedo et al

Andy

Retired committee member
Highlights

Wistar rats were exposed to low levels of BPS and BPA at long-term.
•BPA and BPS alter serum lipid levels and lead to glucose intolerance.
•BPA and BPS improve succinate oxidation and reduce mitochondrial content.
•BPA reduces OXPHOS capacity and uncouples respiration but increases fatty acid oxidation.
•BPA and BPS increase mitochondrial-derived reactive oxygen species.

Abstract
The present study evaluates the effects of low-level long-term exposure to bisphenol A (BPA) and bisphenol S (BPS) on serum biochemical markers, glucose homeostasis, mitochondrial energy metabolism, biogenesis and dynamics, and redox status in livers of Wistar rats. While only the exposure to BPS induces a significant body mass gain after 21 weeks, both compounds alter serum lipid levels and lead to the development of glucose intolerance. Regarding mitochondrial metabolism, both bisphenols augment the electron entry by complex II relative to complex I in the mitochondrial respiratory chain (MRC), and reduce mitochondrial content; BPA reduces OXPHOS capacity and uncouples respiration (relative to maximal capacity of MRC) but promotes a significant increase in fatty acid oxidation. Either exposure to BPA or BPS leads to an increase in mitochondrial-derived reactive oxygen species, mainly at complex I. Additionally, BPA and BPS significantly upregulate the expression levels of dynamin-related protein 1 related to mitochondrial fission, while BPA downregulates the expression of proliferator-activated receptor gamma coactivator 1 alpha, a master regulator of mitochondrial biogenesis. In summary, our data shows that exposure to both compounds alters metabolic homeostasis and mitochondrial energy metabolism, providing new mechanisms by which BPA and BPS impair the mitochondrial metabolism.
Paywall, www.sciencedirect.com/science/article/pii/S0278691519304831
Paywall, https://sci-hub.se/10.1016/j.fct.2019.110694
 
Stuff like this is probably why there are so many chronically ill people nowadays. There are thousands of compounds in our body that are derived from industrial human activity, and have incompletely understood or unknown health effects.

The reaction by the healthcare system appears to be diagnosing everyone with depression.
 
10 years ago.........


https://www.telegraph.co.uk/news/he...ed-to-cancer-in-baby-bottles-campaigners.html

"In a letter to Andy Burnham, Health Secretary, leading scientists said the use of the chemical Bisphenol-A, in baby's bottles and other products used to feed small children, should be banned.


It comes as Breast Cancer UK launched a campaign, No More BPA, to end its use in products for babies.

Professor Vyvyan Howard, of the Biomedical Sciences Research Institute at Ulster University, and one of the signatories, said: "As a medically qualified pathologist and parent to an eight-month old baby boy, I feel that it is essential for the Government to heed our call for precautionary measures to limit exposure of BPA to very young children."

The letters signed by seven experts, including leading specialists in toxicology and cancer prevention, said there was a growing consensus that low levels of the chemical have a significant impact on the risk of cancer, diabetes, impaired brain function and behavioural problems.

They said this had been seen in laboratory animals and although there are still gaps in knowledge about the effect, a precautionary approach should be taken.`'



https://www.pan-europe.info/old/Act...s in Pesticides Residues - Presentation 1.pdf


https://www.canceractive.com/article/professor-vyvyan-howard

This interview with Professor Vyvyan Howard for icon looks at his work on child cancer, and chemical toxins.
vyvyan_howard.jpg

Passionate About Protecting The Future Of Our Childen
By Madeleine Kingsley
Photography by Paul Chave

"Life expectancy has gone up, and we are now living in a soup of carcinogenic influences; clearly the longer you live, the more likely these are to have an effect. Living longer is not itself the cause - it simply exposes you to the causes over a greater period."

"We need to consider all possible factors because cancer is multifactorial and multistage. There will be no magic bullet to erase it."
 
Interesting how a few chemicals are called out as the bad guys, when we probably have many that are carcinogenic, neurotoxic etc. We do indeed live in a toxic soup.
This. Banning one chemical when another much like it is just used in its stead because no research shows the replacement is bad (like BPA and BPS) and then waiting for research to catch up and then do another change.. it's frustrating to say the least.
 
Interesting how a few chemicals are called out as the bad guys, when we probably have many that are carcinogenic, neurotoxic etc. We do indeed live in a toxic soup.

And we always will. Nature creates powerful pesticides, carcinogens and a number of poisons, and humans manufacture more from Nature’t Lego set. There was no days prior to modernity were not clean, harmless and safe; e.g. a wood fire throws off hundreds of carcinogens, while a gas furnace installed to code puts nothing into your home’s air.

In premodern times there was never an expectation of living to one’s 60s in fine health; through most of history those susceptible to whatever nasties were common in their woods or who were merely unlucky tended to die off rather than reach old age. None of us would have made it unless part of a wealthy family, and even then we might well have been discarded.

Chronic disease was less common, instead of that you’d be dead.
 
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