Long-Term Microvascular Changes in Multisystem Inflammatory Syndrome in Children, 2024, Boever et al.

Long-Term Microvascular Changes in Multisystem Inflammatory Syndrome in Children
Julie Boever; Claudia Nussbaum; Leonie Arnold; Nikolaus A. Haas; Simone K. Dold; Felix S. Oberhoffer; André Jakob

No Abstract.

Videos of sublingual microcirculation were obtained with a handheld MicroScan video microscope based on sidestream dark field imaging technology.

Endothelial function (reactive hyperemia index) and arterial stiffness (augmentation index [AI]) were measured by digital arterial plethysmography using the EndoPAT device.

This study found significant, persistent microvascular damage with redistribution of the vessel architecture (ie, loss of capillaries with relative increase in larger vessels) in patients with MIS-C and suggests a long-term association with arterial stiffness. Our findings suggest that MIS-C’s pathogenesis may go beyond the acute hyperinflammatory reaction, possibly involving independent effects of SARS-CoV-2 on the endothelium and vascular system.

Link | PDF (JAMA Pediatrics)