Loss of Transient Receptor Potential Melastatin 3 ion channel function in natural killer cells from CFS/ME (2018) Cabanas, Marshall-Gradisnik et al

https://www.ncbi.nlm.nih.gov/pubmed/30134818
https://molmed.biomedcentral.com/articles/10.1186/s10020-018-0046-1

 

I thought this had been posted already but I couldn't find it. Maybe it was just an early announcement I saw.

 

It was mentioned in a Facebook post discussed here:

https://www.s4me.info/threads/don-staines-and-griffith.5233/#post-94625

 

Interesting result and clear the NCNED team are still pursuing their calcium theory. However (as the limitations section notes), this had only six patients and six controls so, even though it found statistically significant differences between patients and controls, it is in dire need of replication before drawing too much in the way of conclusions. *If* replicated then it would seem to provide a potential explanation for the reduced NK-cell function that has been reported multiple times in ME/CFS studies.

 

TRPM3 transient receptor potential cation channel subfamily M member 3 [ Homo sapiens (human) ]
Gene ID: 80036, updated on 20-Dec-2019

https://www.ncbi.nlm.nih.gov/gene/80036